TY - JOUR
T1 - Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis
AU - Hernández-Gea, Virginia
AU - De Gottardi, Andrea
AU - Leebeek, Frank W.G.
AU - Rautou, Pierre Emmanuel
AU - Salem, Riad
AU - Garcia-Pagan, Juan Carlos
N1 - Funding Information:
This study was supported by the Ministry of Education and Science (SAF-2016-75767-R), and Instituto de Salud Carlos III (PIE15/00027, PI17/00398), FEDER “Una manera de hacer Europa”) in Spain. The Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) is funded by the Instituto de Salud Carlos III, Spain. REHEVASC is partially funded by Asociación Española para Estudio del Hígado (AEEH), Spain. VALDIG is partially funded by EASL and Stiftung für Leberkrankheiten, Bern. This work was also supported by the “Institut National de la Santé et de la Recherche Médicale”, France, and the “Agence Nationale pour la Recherche”, France (ANR-14-CE12-0011, ANR-14-CE35-0022, ANR-18-CE14-0006-01).
Funding Information:
This study was supported by the Ministry of Education and Science ( SAF-2016-75767-R ), and Instituto de Salud Carlos III ( PIE15/00027 , PI17/00398 ), FEDER “Una manera de hacer Europa”) in Spain. The Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd) is funded by the Instituto de Salud Carlos III , Spain. REHEVASC is partially funded by Asociación Española para Estudio del Hígado (AEEH), Spain. VALDIG is partially funded by EASL and Stiftung für Leberkrankheiten , Bern. This work was also supported by the “ Institut National de la Santé et de la Recherche Médicale ”, France, and the “ Agence Nationale pour la Recherche ”, France ( ANR-14-CE12-0011 , ANR-14-CE35-0022 , ANR-18-CE14-0006-01 ).
Publisher Copyright:
© 2019 European Association for the Study of the Liver
PY - 2019/7
Y1 - 2019/7
N2 - Budd-Chiari syndrome and non-cirrhotic non-tumoral portal vein thrombosis are 2 rare disorders, with several similarities that are categorized under the term splanchnic vein thrombosis. Both disorders are frequently associated with an underlying prothrombotic disorder. They can cause severe portal hypertension and usually affect young patients, negatively influencing life expectancy when the diagnosis and treatment are not performed at an early stage. Yet, they have specific features that require individual consideration. The current review will focus on the available knowledge on pathophysiology, diagnosis and management of both entities.
AB - Budd-Chiari syndrome and non-cirrhotic non-tumoral portal vein thrombosis are 2 rare disorders, with several similarities that are categorized under the term splanchnic vein thrombosis. Both disorders are frequently associated with an underlying prothrombotic disorder. They can cause severe portal hypertension and usually affect young patients, negatively influencing life expectancy when the diagnosis and treatment are not performed at an early stage. Yet, they have specific features that require individual consideration. The current review will focus on the available knowledge on pathophysiology, diagnosis and management of both entities.
KW - Angioplasty
KW - Coagulopathy
KW - Portal hypertension
KW - Portal vein thrombosis
KW - TIPS
KW - Thrombophilia
KW - Transplant
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U2 - 10.1016/j.jhep.2019.02.015
DO - 10.1016/j.jhep.2019.02.015
M3 - Review article
C2 - 30822449
AN - SCOPUS:85064533188
SN - 0168-8278
VL - 71
SP - 175
EP - 199
JO - Journal of Hepatology
JF - Journal of Hepatology
IS - 1
ER -
