Current knowledge in pathophysiology and management of Budd-Chiari syndrome and non-cirrhotic non-tumoral splanchnic vein thrombosis

Virginia Hernández-Gea, Andrea De Gottardi, Frank W.G. Leebeek, Pierre Emmanuel Rautou, Riad Salem, Juan Carlos Garcia-Pagan*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations

Abstract

Budd-Chiari syndrome and non-cirrhotic non-tumoral portal vein thrombosis are 2 rare disorders, with several similarities that are categorized under the term splanchnic vein thrombosis. Both disorders are frequently associated with an underlying prothrombotic disorder. They can cause severe portal hypertension and usually affect young patients, negatively influencing life expectancy when the diagnosis and treatment are not performed at an early stage. Yet, they have specific features that require individual consideration. The current review will focus on the available knowledge on pathophysiology, diagnosis and management of both entities.

Original languageEnglish (US)
Pages (from-to)175-199
Number of pages25
JournalJournal of Hepatology
Volume71
Issue number1
DOIs
StatePublished - Jul 2019

Keywords

  • Angioplasty
  • Coagulopathy
  • Portal hypertension
  • Portal vein thrombosis
  • TIPS
  • Thrombophilia
  • Transplant

ASJC Scopus subject areas

  • Hepatology

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