Current management of thrombotic thrombocytopenic purpura

J. J. Hong, Hau C. Kwaan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Historically, the mortality rate of thrombotic thrombocytopenic purpura (TTP) approached 100%. However, by the 1980's, new therapy was instituted with a vast improvement in survival to 90%. The exact pathogenesis of TTP remains elusive. Yet, despite incomplete understanding of the pathophysiology, outcome has improved due to increased awareness of the symptomatology leading to earlier diagnosis and better supportive care, in addition to effective therapy with plasma exchange. TTP represents a disease in which prompt diagnosis and treatment can lead to a critical difference in clinical outcome.

Original languageEnglish (US)
Pages (from-to)461-469
Number of pages9
JournalHematology
Volume4
Issue number6
StatePublished - May 3 2000

Keywords

  • Cryosupernatant
  • Fresh frozen plasma
  • Plasma exchange
  • Thrombotic thrombocytopenic purpura
  • Von Wille-brand factor

ASJC Scopus subject areas

  • Hematology

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