Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer

Yeqing Angela Yang, Jindan Yu*

*Corresponding author for this work

Research output: Contribution to journalReview article

36 Scopus citations

Abstract

FOXA1 (also known as hepatocyte nuclear factor 3α, or HNF-3α) is a protein of the FKHD family transcription factors. FOXA1 has been termed as a pioneer transcription factor due to its unique ability of chromatin remodeling in which the chromatin can be de-compacted to allow genomic access by nuclear hormone receptors, including androgen receptor (AR) and estrogen receptor (ER). In this review, we discuss our current understanding of FOXA1 regulation of prostatic and non-prostatic AR-chromatin targeting. We present an updated model wherein FOXA1:AR equilibrium in the nuclei defines prostatic AR binding profile, which is perturbed in prostate cancer with FOXA1 and/or AR de-regulation. Finally, we discuss recent efforts in exploring new horizons of AR-independent functions of FOXA1 in prostate cancer and interesting directions to pursue in future studies.

Original languageEnglish (US)
Pages (from-to)144-151
Number of pages8
JournalGenes and Diseases
Volume2
Issue number2
DOIs
StatePublished - Jun 1 2015

Keywords

  • Androgen receptor
  • Chromatin accessibility
  • EMT
  • FOXA1
  • Pioneering factor
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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