Current practice of pharmacological thromboprophylaxis for prevention of venous thromboembolism in hospitalized children: A survey of pediatric hemostasis and thrombosis experts in North America

Sherif M. Badawy, Karen Rychlik, Anjali A. Sharathkumar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Pharmacological thromboprophylaxis (pTP) is the most effective intervention to prevent venous thromboembolism (VTE) in hospitalized adults. High-quality studies investigating the role of pTP in children are lacking. The aim of this study is to understand pediatric hematologists' current practices of pTP prescription and to explore their opinion about universal adoption of pTP for high-risk hospitalized children. An electronic survey was sent to members of Hemostasis and Thrombosis Research Society of North America. The response rate was 47.3% (53/112). VTE was perceived as a major hospital acquired complication by all and 96% (51/53) prescribed pTP in select cases.Majority would consider prescribing pTP for personal history of thrombosis, inheritance of severe thrombophilic conditions, and teen age. The majority of respondents (55%, 29/53) were either not in support of or uncertain about the universal adoption of pTP policy for high-risk hospitalized children. In total, 62% of respondents (33/53) did not support the use of pTP for central venous lines. Respondents reported on the presence of pharmacological (32%, 17/53) and mechanical (45%, 24/53) thromboprophylaxis policies at their institutions. Pediatric hematologists considered pTP a useful intervention to prevent VTE and prescribed pTP in select cases. Universal adoption of pTP was not supported. Wide variability in clinical practice was observed.

Original languageEnglish (US)
Pages (from-to)301-307
Number of pages7
JournalJournal of pediatric hematology/oncology
Volume38
Issue number4
DOIs
StatePublished - Jan 1 2016

Fingerprint

Hospitalized Child
Venous Thromboembolism
North America
Hemostasis
Thrombosis
Pharmacology
Pediatrics
Surveys and Questionnaires
Prescriptions

Keywords

  • Hospitalized children
  • Pharmacological thromboprophylaxis
  • Thromboprophylaxis
  • Thrombosis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

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title = "Current practice of pharmacological thromboprophylaxis for prevention of venous thromboembolism in hospitalized children: A survey of pediatric hemostasis and thrombosis experts in North America",
abstract = "Pharmacological thromboprophylaxis (pTP) is the most effective intervention to prevent venous thromboembolism (VTE) in hospitalized adults. High-quality studies investigating the role of pTP in children are lacking. The aim of this study is to understand pediatric hematologists' current practices of pTP prescription and to explore their opinion about universal adoption of pTP for high-risk hospitalized children. An electronic survey was sent to members of Hemostasis and Thrombosis Research Society of North America. The response rate was 47.3{\%} (53/112). VTE was perceived as a major hospital acquired complication by all and 96{\%} (51/53) prescribed pTP in select cases.Majority would consider prescribing pTP for personal history of thrombosis, inheritance of severe thrombophilic conditions, and teen age. The majority of respondents (55{\%}, 29/53) were either not in support of or uncertain about the universal adoption of pTP policy for high-risk hospitalized children. In total, 62{\%} of respondents (33/53) did not support the use of pTP for central venous lines. Respondents reported on the presence of pharmacological (32{\%}, 17/53) and mechanical (45{\%}, 24/53) thromboprophylaxis policies at their institutions. Pediatric hematologists considered pTP a useful intervention to prevent VTE and prescribed pTP in select cases. Universal adoption of pTP was not supported. Wide variability in clinical practice was observed.",
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