Current role of hepatic artery infusion and isolated liver perfusion for the treatment of colorectal cancer liver metastases

Dina M. Elaraj, H. Richard Alexander*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

There are many treatment options for patients with metastatic colorectal carcinoma confined to the liver. Surgical resection alone can result in significant prolongation of survival in patients with favorable prognostic factors. Randomized studies of hepatic artery infusion therapy after complete resection of liver metastases have demonstrated improvements in hepatic recurrence-free survival but no impact on overall survival. Randomized trials evaluating the treatment of unresectable disease with hepatic artery infusion therapy have demonstrated higher response rates (31%-50%) than those seen with systemic chemotherapy (8%-20%) but no survival benefit. Vascular isolation and perfusion of the liver with chemotherapy with or without biologic agents under hyperthermic conditions is another regional modality that has been explored for the treatment of unresectable colorectal cancer liver metastases. Large series report high partial response rates (68%-77%), with responses being achieved in patients with advanced tumor burden and in those who have disease progression through prior treatment of hepatic metastases.

Original languageEnglish (US)
Pages (from-to)128-138
Number of pages11
JournalCancer Journal
Volume10
Issue number2
DOIs
StatePublished - Mar 1 2004

Keywords

  • Colorectal neoplasms
  • Hyperthermia
  • Isolation perfusion
  • Liver
  • Neoplasm metastases
  • Perfusion
  • Regional

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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