TY - JOUR
T1 - Current State of Knowledge on Implications of Gut Microbiome for Surgical Conditions
AU - Chen, Edmund B.
AU - Cason, Cori
AU - Gilbert, Jack A.
AU - Ho, Karen J.
N1 - Funding Information:
Funding This work was funded in part by T32HL094293 (to E.C. and C.C.); Abbott Fund (to E.C.); K08HL130601 (to K.H.) from the National Heart, Lung, and Blood Institute; American College of Surgeons/Society of Vascular Surgery (to K.H.); Vascular Cures (to K.H.); and National Institute of Justice award 2017-MU-MU-0042 (to J.A.G.)
Publisher Copyright:
© 2018, The Society for Surgery of the Alimentary Tract.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - The role of the microbiome in human health has become a central tenant of current medical research, infiltrating a diverse disciplinary base whereby microbiology, computer science, ecology, gastroenterology, immunology, neurophysiology and psychology, metabolism, and cardiovascular medicine all intersect. Traditionally, commensal gut microbiota have been assumed to play a significant role only in the metabolic processing of dietary nutrients and host metabolites, the fortification of gut epithelial barrier function, and the development of mucosal immunity. However, over the last 20 years, new technologies and renewed interest have uncovered a considerably broader influence of the microbiota on health maintenance and disease development, many of which are of particular relevance for surgeons. This article provides a broad overview of the current state of knowledge and a review of the technology that helped in their formation.
AB - The role of the microbiome in human health has become a central tenant of current medical research, infiltrating a diverse disciplinary base whereby microbiology, computer science, ecology, gastroenterology, immunology, neurophysiology and psychology, metabolism, and cardiovascular medicine all intersect. Traditionally, commensal gut microbiota have been assumed to play a significant role only in the metabolic processing of dietary nutrients and host metabolites, the fortification of gut epithelial barrier function, and the development of mucosal immunity. However, over the last 20 years, new technologies and renewed interest have uncovered a considerably broader influence of the microbiota on health maintenance and disease development, many of which are of particular relevance for surgeons. This article provides a broad overview of the current state of knowledge and a review of the technology that helped in their formation.
KW - Gastrointestinal tract
KW - Medicine
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=85045071238&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85045071238&partnerID=8YFLogxK
U2 - 10.1007/s11605-018-3755-4
DO - 10.1007/s11605-018-3755-4
M3 - Review article
C2 - 29623674
AN - SCOPUS:85045071238
SN - 1091-255X
VL - 22
SP - 1112
EP - 1123
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
IS - 6
ER -
