Current State of Knowledge on Implications of Gut Microbiome for Surgical Conditions

Edmund B. Chen, Cori Cason, Jack A. Gilbert, Karen J. Ho*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Scopus citations

Abstract

The role of the microbiome in human health has become a central tenant of current medical research, infiltrating a diverse disciplinary base whereby microbiology, computer science, ecology, gastroenterology, immunology, neurophysiology and psychology, metabolism, and cardiovascular medicine all intersect. Traditionally, commensal gut microbiota have been assumed to play a significant role only in the metabolic processing of dietary nutrients and host metabolites, the fortification of gut epithelial barrier function, and the development of mucosal immunity. However, over the last 20 years, new technologies and renewed interest have uncovered a considerably broader influence of the microbiota on health maintenance and disease development, many of which are of particular relevance for surgeons. This article provides a broad overview of the current state of knowledge and a review of the technology that helped in their formation.

Original languageEnglish (US)
Pages (from-to)1112-1123
Number of pages12
JournalJournal of Gastrointestinal Surgery
Volume22
Issue number6
DOIs
StatePublished - Jun 1 2018

Keywords

  • Gastrointestinal tract
  • Medicine
  • Microbiota

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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