While the initial therapy for acute myeloid leukaemia (AML) treatment is relatively standardised, the high incidence of refractory/relapsed disease remains a great challenge. Progress has been made in understanding the pathophysiology of both initial and recurrent disease phases, leading to rigorous pre-clinical studies to identify and selectively target cellular pathways that promote leukaemogenesis. In this article, we discuss the ongoing efforts in overcoming relapsed disease, through a literature-based examination of primary papers and clinical trials, focusing on specific targets and their exploitation for future therapeutic development. The main focus of this article is to review therapies targeting CREB, Triad1, the BCL-2 family and JAK/STAT.
- Acute myeloid leukaemia (AML)
- Napthol AS-e
ASJC Scopus subject areas
- Pharmacology (medical)