Current trends in immunosuppression for lung transplantation

Timothy Floreth, Sangeeta M. Bhorade

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

Lung transplant has become an established therapy in the treatment of end-stage lung disease. Many of the advances in the modern immunosuppression regimen have provided more quality and quantity of life to transplant patients. Immunosuppression agents target various aspects of the immune system to maximize graft tolerance while minimizing medication toxicities and side effects. Lung transplant regimens follow typical protocols but are always tailored to the individual patient based upon previous and current medical problems. Despite the various advances, acute and chronic rejections still occur in the majority of all lung transplants. For these reasons, long-term lung transplantation success remains a challenge. Further improvement in immunosuppression will be geared toward minimizing rejection and infection as well as being tailored to the individual patient. This review details the current armamentarium of immunosuppression medications and the current body of evidence supporting the current trends of usage.

Original languageEnglish (US)
Pages (from-to)172-178
Number of pages7
JournalSeminars in Respiratory and Critical Care Medicine
Volume31
Issue number2
DOIs
StatePublished - Apr 13 2010

Keywords

  • Antimetabolites
  • Calcineurin inhibitors
  • Immunosuppression
  • Induction therapy
  • Lung transplantation

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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