Current views on the function of the lymphatic vasculature in health and disease

Yingdi Wang, Guillermo Oliver*

*Corresponding author for this work

Research output: Contribution to journalReview article

101 Scopus citations

Abstract

The lymphatic vascular system is essential for lipid absorption, fluid homeostasis, and immune surveillance. Until recently, lymphatic vessel dysfunction had been associated with symptomatic pathologic conditions such as lymphedema. Work in the last few years had led to a better understanding of the functional roles of this vascular system in health and disease. Furthermore, recent work has also unraveled additional functional roles of the lymphatic vasculature in fat metabolism, obesity, inflammation, and the regulation of salt storage in hypertension. In this review, we summarize the functional roles of the lymphatic vasculature in health and disease.

Original languageEnglish (US)
Pages (from-to)2115-2126
Number of pages12
JournalGenes and Development
Volume24
Issue number19
DOIs
StatePublished - Oct 1 2010

Keywords

  • Inflammation
  • Lymphangiogenesis
  • Lymphatic vasculature
  • Metabolism
  • Obesity
  • Prox1
  • Tumors

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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