Cushing's syndrome (CS), secondary to paraneoplastic syndrome, is more commonly seen in small cell lung cancer but never before reported in epidermal growth factor receptor-mutated adenocarcinoma of the lung. Here, we present a case of a patient whose symptoms of hypokalemia, hypertension, and progressive abnormal glucose levels led to further workup that revealed adrenocorticotropic hormone-dependent hypercortisolism. Her cortisol levels dropped after 1 month of osilodrostat treatment, while lung cancer was treated with osimertinib. The use of osilodrostat in paraneoplastic CS has been previously reported in only 3 patients.
- Case report
- Ectopic adrenocorticotropic hormone-dependent Cushing
- Epidermal growth factor receptor
ASJC Scopus subject areas
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Heleno, C. T. (Contributor), Hong, S. P. D. (Contributor), Cho, H. (Contributor), Kim, M. J. (Contributor), Park, Y. (Contributor) & Chae, Y. K. (Contributor), Karger Publishers, 2023