Cutaneous Allergy to Human (Recombinant DNA) Insulin

Leslie C. Grammer; Boyd E. Metzger; Roy Patterson

doi:10.1001/jama.1984.03340350049027

Cutaneous Allergy to Human (Recombinant DNA) Insulin

Leslie C. Grammer^*, Boyd E. Metzger, Roy Patterson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We report two cases of cutaneous allergy to human (recombinant DNA) insulin. Each patient had a history of systemic allergic reactions to porcine insulin and was at least as reactive to human as to porcine insulin by end-point cutaneous titration. Both patients' insulin allergy was managed with animal insulins and both have done well. Our experience with these two patients indicates that human insulin (rDNA) should not be expected to be efficacious in all patients with systemic allergy to insulin.

Original language	English (US)
Pages (from-to)	1459-1460
Number of pages	2
Journal	JAMA: The Journal of the American Medical Association
Volume	251
Issue number	11
DOIs	https://doi.org/10.1001/jama.1984.03340350049027
State	Published - Mar 16 1984

ASJC Scopus subject areas

General Medicine

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abstract = "We report two cases of cutaneous allergy to human (recombinant DNA) insulin. Each patient had a history of systemic allergic reactions to porcine insulin and was at least as reactive to human as to porcine insulin by end-point cutaneous titration. Both patients' insulin allergy was managed with animal insulins and both have done well. Our experience with these two patients indicates that human insulin (rDNA) should not be expected to be efficacious in all patients with systemic allergy to insulin.",

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AU - Patterson, Roy

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N2 - We report two cases of cutaneous allergy to human (recombinant DNA) insulin. Each patient had a history of systemic allergic reactions to porcine insulin and was at least as reactive to human as to porcine insulin by end-point cutaneous titration. Both patients' insulin allergy was managed with animal insulins and both have done well. Our experience with these two patients indicates that human insulin (rDNA) should not be expected to be efficacious in all patients with systemic allergy to insulin.

AB - We report two cases of cutaneous allergy to human (recombinant DNA) insulin. Each patient had a history of systemic allergic reactions to porcine insulin and was at least as reactive to human as to porcine insulin by end-point cutaneous titration. Both patients' insulin allergy was managed with animal insulins and both have done well. Our experience with these two patients indicates that human insulin (rDNA) should not be expected to be efficacious in all patients with systemic allergy to insulin.

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Cutaneous Allergy to Human (Recombinant DNA) Insulin

Abstract

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