Cutaneous Allergy to Human (Recombinant DNA) Insulin

Leslie C. Grammer*, Boyd E. Metzger, Roy Patterson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


We report two cases of cutaneous allergy to human (recombinant DNA) insulin. Each patient had a history of systemic allergic reactions to porcine insulin and was at least as reactive to human as to porcine insulin by end-point cutaneous titration. Both patients' insulin allergy was managed with animal insulins and both have done well. Our experience with these two patients indicates that human insulin (rDNA) should not be expected to be efficacious in all patients with systemic allergy to insulin.

Original languageEnglish (US)
Pages (from-to)1459-1460
Number of pages2
JournalJAMA: The Journal of the American Medical Association
Issue number11
StatePublished - Mar 16 1984

ASJC Scopus subject areas

  • Medicine(all)


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