Cutaneous Ganglioneuromas With Overlying Epidermal Hyperplasia: A Case Series Presentation and Proposal of Potential Etiopathogenesis

Connor R. Zuraski, Cameron Wales, Cuong V. Nguyen, Edward F. Chan, Carrie Kovarik, John T. Seykora, Rosalie Elenitsas, Ata S. Moshiri*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Cutaneous ganglioneuromas (GNs) are exceptionally uncommon tumors, and many reported cases describe association with overlying epidermal hyperplasia that may be interpreted as seborrheic keratosis (SK) or SK-like proliferation. We report 5 cases of cutaneous GN in adult patients; all of which were discovered incidentally in the immediate vicinity of epidermal hyperplasia. A review of the literature demonstrates the current- A lthough likely imperfect-understanding of the etiopathogenesis of both SK and GN in the skin. We explore the putative pathophysiologies of other common, well-characterized skin lesions and, taking them into account, provide rationale for the coexistence of cutaneous GN with overlying SK and SK-like epidermal changes. However, we ultimately acknowledge a dilemma of causality and, given the rarity of their co-occurrence, objectively question whether occasional cameo appearances by GN lying subjacent to SK and SK-like hyperplasia may be due merely to chance.

Original languageEnglish (US)
Pages (from-to)812-816
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume44
Issue number11
DOIs
StatePublished - Nov 1 2022

Keywords

  • cutaneous
  • epidermal hyperplasia
  • ganglioneuroma
  • seborrheic keratosis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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