Abstract
Cutaneous ganglioneuromas (GNs) are exceptionally uncommon tumors, and many reported cases describe association with overlying epidermal hyperplasia that may be interpreted as seborrheic keratosis (SK) or SK-like proliferation. We report 5 cases of cutaneous GN in adult patients; all of which were discovered incidentally in the immediate vicinity of epidermal hyperplasia. A review of the literature demonstrates the current- A lthough likely imperfect-understanding of the etiopathogenesis of both SK and GN in the skin. We explore the putative pathophysiologies of other common, well-characterized skin lesions and, taking them into account, provide rationale for the coexistence of cutaneous GN with overlying SK and SK-like epidermal changes. However, we ultimately acknowledge a dilemma of causality and, given the rarity of their co-occurrence, objectively question whether occasional cameo appearances by GN lying subjacent to SK and SK-like hyperplasia may be due merely to chance.
Original language | English (US) |
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Pages (from-to) | 812-816 |
Number of pages | 5 |
Journal | American Journal of Dermatopathology |
Volume | 44 |
Issue number | 11 |
DOIs | |
State | Published - Nov 1 2022 |
Keywords
- cutaneous
- epidermal hyperplasia
- ganglioneuroma
- seborrheic keratosis
ASJC Scopus subject areas
- Dermatology
- Pathology and Forensic Medicine