Cutaneous injury following acute UV-B radiation in a mouse model: A pilot histological study

Tapan K. Bhattacharyya, Bennett E. Barch, Maria Vargas, James Regan Thomas

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Epidemiological and clinical studies have implicated solar ultraviolet (UV) radiation, especially the UV-B radiation (290-320 nm wavelengths) as the principal agent that elicits sunburn, transient inflammation, melanoma and non-melanoma cancer, and premature skin aging. The common form of skin damage described as 'photoaging' is caused by repeated sun exposures; it can induce epithelial deoxyribonucleic acid (DNA) damage, and alter the structure and function of dermal connective tissue and extracellular matrix. The present study was aimed to elucidate the effects of a single exposure of different doses of UV-B radiation on the dorsal skin in the hairless mouse. The histopathologic sequels of such exposures were analyzed by using common staining methods, immunohistochemistry, and histomorphometry. Single UV-B exposures seem to elicit dose-graded histological changes some of which have been described in experiments with chronic exposure in this species.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalJournal of Histotechnology
Volume36
Issue number2
DOIs
StatePublished - May 1 2013

Keywords

  • Hairless mouse
  • Herovici stain
  • Histopathology
  • Mouse skin
  • Photoaging
  • UV-B radiation

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Medical Laboratory Technology

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