Cutaneous manifestations of pediatric lupus

Lisa M. Arkin*, Cordellia Nguyen, Marisa Klein-Gitelman

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Purpose of review To review recent evidence on cutaneous manifestations of lupus, with a focus on evidence for pediatric patients. Recent findings Cutaneous manifestations of SLE are common and may precede signs or symptoms of systemic disease. Early recognition and initiation of therapy improves quality of life by reducing cutaneous disease activity. Antimalarials are first line for moderate-to-severe disease. Photo protection is a critical component of therapy and perhaps the only modifiable risk factor for SLE. Recognition of cutaneous vasculopathy may reduce mortality from vascular occlusion. Summary There is a critical need for better understanding of pathogenesis, risk factors and outcomes in cutaneous lupus to determine optimal treatment and surveillance strategies. Correlation of clinical phenotypes with biomarkers may help to stratify patients, optimize targeted interventions, and influence prognosis.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalCurrent opinion in rheumatology
Volume31
Issue number5
DOIs
StatePublished - Sep 1 2019

Keywords

  • Cutaneous lupus erythematosus
  • Cutaneous manifestations of systemic disease
  • Pediatric
  • Scarring
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

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