Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report

Blake E. Vest; Christina L. Harview; Vincent Liu; Brian L. Swick; Kristen G. Berrebi; Shantel Olivares; Mary S. Stone; Michael R. Sargen; Pedram Gerami

doi:10.1111/cup.14287

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report

Blake E. Vest, Christina L. Harview, Vincent Liu, Brian L. Swick, Kristen G. Berrebi, Shantel Olivares, Mary S. Stone, Michael R. Sargen, Pedram Gerami^*

^*Corresponding author for this work

Dermatology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.

Original language	English (US)
Pages (from-to)	1025-1030
Number of pages	6
Journal	Journal of cutaneous pathology
Volume	49
Issue number	12
DOIs	https://doi.org/10.1111/cup.14287
State	Published - Dec 2022

Keywords

CRTC1
TRIM11
case report
clear cell sarcoma
melanocytoma

ASJC Scopus subject areas

Dermatology
Pathology and Forensic Medicine
Histology

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10.1111/cup.14287

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@article{6ba73e0978aa46d0baac0f8f20f99f82,

title = "Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report",

abstract = "Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.",

keywords = "CRTC1, TRIM11, case report, clear cell sarcoma, melanocytoma",

author = "Vest, {Blake E.} and Harview, {Christina L.} and Vincent Liu and Swick, {Brian L.} and Berrebi, {Kristen G.} and Shantel Olivares and Stone, {Mary S.} and Sargen, {Michael R.} and Pedram Gerami",

note = "Funding Information: The authors would like to thank the patient and her family for allowing them to share this case and Dr Rachel Koziczkowski for referring the patient to the institution and giving the opportunity to participate in her care. Publisher Copyright: {\textcopyright} 2022 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.",

year = "2022",

month = dec,

doi = "10.1111/cup.14287",

language = "English (US)",

volume = "49",

pages = "1025--1030",

journal = "Journal of cutaneous pathology",

issn = "0303-6987",

publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report

AU - Vest, Blake E.

AU - Harview, Christina L.

AU - Liu, Vincent

AU - Swick, Brian L.

AU - Berrebi, Kristen G.

AU - Olivares, Shantel

AU - Stone, Mary S.

AU - Sargen, Michael R.

AU - Gerami, Pedram

N1 - Funding Information: The authors would like to thank the patient and her family for allowing them to share this case and Dr Rachel Koziczkowski for referring the patient to the institution and giving the opportunity to participate in her care. Publisher Copyright: © 2022 The Authors. Journal of Cutaneous Pathology published by John Wiley & Sons Ltd.

PY - 2022/12

Y1 - 2022/12

N2 - Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.

AB - Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion (CMCT) is a recently described entity with only 13 cases reported in the literature. Histopathologically, the neoplasm consists of atypical epithelioid to spindled cells that form a well-circumscribed nodule usually confined to the dermis and subcutis with cytological features including large vesicular nuclei with prominent nucleoli and abundant eosinophilic cytoplasm. Immunohistochemistry shows variable expressivity of melanocytic markers. Currently, there are limited data regarding long-term outcomes of this newly described entity. Most cases have done well, but there is one case reported with an adverse event. Hence, further studies are needed to accurately classify this tumor. Definitive diagnosis is made by laboratory evidence of CMCT. Herein, we report the first case of CMCT with epidermal involvement in the youngest patient known to be affected to date.

KW - CRTC1

KW - TRIM11

KW - case report

KW - clear cell sarcoma

KW - melanocytoma

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Cutaneous melanocytic tumor with CRTC1::TRIM11 fusion and prominent epidermal involvement: A case report

Abstract

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