TY - JOUR
T1 - Cutting edge
T2 - Both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity
AU - Robbie-Ryan, Michaela
AU - Tanzola, Melinda B.
AU - Secor, Virginia H.
AU - Brown, Melissa A.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2003/2/15
Y1 - 2003/2/15
N2 - Mast cell-deficient mice (W/Wv) exhibit significantly reduced severity of experimental allergic encephalomyelitis (EAE), a murine model of multiple sclerosis. In this study, the contribution of FcR-mediated mast cell activation to disease was examined. W/Wv mice were reconstituted i. v. with bone marrow-derived mast cells (BMMCs) from wild-type mice or those lacking functional FcRs. Eight weeks later, EAE was induced by immunization with the myelin oligodendrocyte glycoprotein 35-55 peptide. Disease scores were analyzed in reconstituted mice and compared with age-matched W/Wv mice and wild-type littermates. Mice reconstituted with FcRγ-/- BMMCs or FcγRIII-/- BMMCs exhibited less severe clinical symptoms similar to W/Wv controls, while reconstitution with FcRIIB-/- BMMCs resulted in disease significantly more severe than wild-type controls. Notably, mice reconstituted with FcγRIII-/- BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE.
AB - Mast cell-deficient mice (W/Wv) exhibit significantly reduced severity of experimental allergic encephalomyelitis (EAE), a murine model of multiple sclerosis. In this study, the contribution of FcR-mediated mast cell activation to disease was examined. W/Wv mice were reconstituted i. v. with bone marrow-derived mast cells (BMMCs) from wild-type mice or those lacking functional FcRs. Eight weeks later, EAE was induced by immunization with the myelin oligodendrocyte glycoprotein 35-55 peptide. Disease scores were analyzed in reconstituted mice and compared with age-matched W/Wv mice and wild-type littermates. Mice reconstituted with FcRγ-/- BMMCs or FcγRIII-/- BMMCs exhibited less severe clinical symptoms similar to W/Wv controls, while reconstitution with FcRIIB-/- BMMCs resulted in disease significantly more severe than wild-type controls. Notably, mice reconstituted with FcγRIII-/- BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE.
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U2 - 10.4049/jimmunol.170.4.1630
DO - 10.4049/jimmunol.170.4.1630
M3 - Article
C2 - 12574324
AN - SCOPUS:0037442191
VL - 170
SP - 1630
EP - 1634
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 4
ER -