Cutting edge: Both activating and inhibitory Fc receptors expressed on mast cells regulate experimental allergic encephalomyelitis disease severity

Michaela Robbie-Ryan, Melinda B. Tanzola, Virginia H. Secor, Melissa A. Brown*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

Mast cell-deficient mice (W/Wv) exhibit significantly reduced severity of experimental allergic encephalomyelitis (EAE), a murine model of multiple sclerosis. In this study, the contribution of FcR-mediated mast cell activation to disease was examined. W/Wv mice were reconstituted i. v. with bone marrow-derived mast cells (BMMCs) from wild-type mice or those lacking functional FcRs. Eight weeks later, EAE was induced by immunization with the myelin oligodendrocyte glycoprotein 35-55 peptide. Disease scores were analyzed in reconstituted mice and compared with age-matched W/Wv mice and wild-type littermates. Mice reconstituted with FcRγ-/- BMMCs or FcγRIII-/- BMMCs exhibited less severe clinical symptoms similar to W/Wv controls, while reconstitution with FcRIIB-/- BMMCs resulted in disease significantly more severe than wild-type controls. Notably, mice reconstituted with FcγRIII-/- BMMC exhibit a relapsing-remitting course of disease. These data demonstrate that both activating and inhibitory FcRs expressed on mast cells influence the course of EAE.

Original languageEnglish (US)
Pages (from-to)1630-1634
Number of pages5
JournalJournal of Immunology
Volume170
Issue number4
DOIs
StatePublished - Feb 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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