Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation

Haiyan Ying, Lifen Yang, Guilin Qiao, Zhenping Li, Li Zhang, Fei Yin, Dong Xie*, Jian Zhang

*Corresponding author for this work

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Th cells that produce IL-17 (Th17 cells) are a distinct subset of Th cells implicated in several autoimmune diseases. Although CD28-B7 interaction has been shown to be involved in Th17 differentiation in vitro, the role of CTLA-4 in controlling Th17 development is completely unknown. We report in this paper that blocking the CTLA-4-B7 interaction potentiates Th17 cell differentiation in vitro and in vivo. Furthermore, blocking CTLA-4-B7 interaction in vivo confers the susceptibility of experimental autoimmune myocarditis to CD28-/- mice or increases the severity of experimental autoimmune myocarditis in wild-type mice. The enhanced disease susceptibility is mediated by heightened Th17 responses. With these results, we are the first to demonstrate that CTLA-4-B7 interaction inhibits Th17 differentiation in vitro and in vivo and suppresses Th17-mediated autoimmunity.

Original languageEnglish (US)
Pages (from-to)1375-1378
Number of pages4
JournalJournal of Immunology
Volume185
Issue number3
DOIs
StatePublished - Aug 1 2010

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Ying, H., Yang, L., Qiao, G., Li, Z., Zhang, L., Yin, F., Xie, D., & Zhang, J. (2010). Cutting edge: CTLA-4-B7 interaction suppresses Th17 cell differentiation. Journal of Immunology, 185(3), 1375-1378. https://doi.org/10.4049/jimmunol.0903369