Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1

Renée F. De Pooter, Sheila Dias, Munmun Chowdhury, Elisabeth T. Bartom, Michael K. Okoreeh, Mikael Sigvardsson, Barbara L. Kee*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)2837-2842
Number of pages6
JournalJournal of Immunology
Volume202
Issue number10
DOIs
StatePublished - May 15 2019

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

De Pooter, R. F., Dias, S., Chowdhury, M., Bartom, E. T., Okoreeh, M. K., Sigvardsson, M., & Kee, B. L. (2019). Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1. Journal of Immunology, 202(10), 2837-2842. https://doi.org/10.4049/jimmunol.1801220