Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1

Renée F. De Pooter, Sheila Dias, Munmun Chowdhury, Elisabeth T. Bartom, Michael K. Okoreeh, Mikael Sigvardsson, Barbara L. Kee*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)2837-2842
Number of pages6
JournalJournal of Immunology
Volume202
Issue number10
DOIs
StatePublished - May 15 2019

Fingerprint

Hematopoietic Stem Cells
Basic Helix-Loop-Helix Transcription Factors
Transcription Factors
Stem Cells
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Erythropoiesis
Lymphocytes
T-Lymphocytes
Genes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

De Pooter, R. F., Dias, S., Chowdhury, M., Bartom, E. T., Okoreeh, M. K., Sigvardsson, M., & Kee, B. L. (2019). Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1. Journal of Immunology, 202(10), 2837-2842. https://doi.org/10.4049/jimmunol.1801220
De Pooter, Renée F. ; Dias, Sheila ; Chowdhury, Munmun ; Bartom, Elisabeth T. ; Okoreeh, Michael K. ; Sigvardsson, Mikael ; Kee, Barbara L. / Cutting edge : Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1. In: Journal of Immunology. 2019 ; Vol. 202, No. 10. pp. 2837-2842.
@article{a0d8f8def7ac4af0a7e05e537e934b8a,
title = "Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1",
abstract = "Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.",
author = "{De Pooter}, {Ren{\'e}e F.} and Sheila Dias and Munmun Chowdhury and Bartom, {Elisabeth T.} and Okoreeh, {Michael K.} and Mikael Sigvardsson and Kee, {Barbara L.}",
year = "2019",
month = "5",
day = "15",
doi = "10.4049/jimmunol.1801220",
language = "English (US)",
volume = "202",
pages = "2837--2842",
journal = "Journal of Immunology",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "10",

}

De Pooter, RF, Dias, S, Chowdhury, M, Bartom, ET, Okoreeh, MK, Sigvardsson, M & Kee, BL 2019, 'Cutting edge: Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1', Journal of Immunology, vol. 202, no. 10, pp. 2837-2842. https://doi.org/10.4049/jimmunol.1801220

Cutting edge : Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1. / De Pooter, Renée F.; Dias, Sheila; Chowdhury, Munmun; Bartom, Elisabeth T.; Okoreeh, Michael K.; Sigvardsson, Mikael; Kee, Barbara L.

In: Journal of Immunology, Vol. 202, No. 10, 15.05.2019, p. 2837-2842.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cutting edge

T2 - Lymphomyeloid-primed progenitor cell fates are controlled by the transcription factor TAL1

AU - De Pooter, Renée F.

AU - Dias, Sheila

AU - Chowdhury, Munmun

AU - Bartom, Elisabeth T.

AU - Okoreeh, Michael K.

AU - Sigvardsson, Mikael

AU - Kee, Barbara L.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

AB - Lymphoid specification is the process by which hematopoietic stem cells (HSCs) and their progeny become restricted to differentiation through the lymphoid lineages. The basic helix-loop-helix transcription factors E2A and Lyl1 form a complex that promotes lymphoid specification. In this study, we demonstrate that Tal1, a Lyl1-related basic helix-loop-helix transcription factor that promotes T acute lymphoblastic leukemia and is required for HSC specification, erythropoiesis, and megakaryopoiesis, is a negative regulator of murine lymphoid specification. We demonstrate that Tal1 limits the expression of multiple E2A target genes in HSCs and controls the balance of myeloid versus T lymphocyte differentiation potential in lymphomyeloid-primed progenitors. Our data provide insight into the mechanisms controlling lymphocyte specification and may reveal a basis for the unique functions of Tal1 and Lyl1 in T acute lymphoblastic leukemia.

UR - http://www.scopus.com/inward/record.url?scp=85065678622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065678622&partnerID=8YFLogxK

U2 - 10.4049/jimmunol.1801220

DO - 10.4049/jimmunol.1801220

M3 - Article

C2 - 30962294

AN - SCOPUS:85065678622

VL - 202

SP - 2837

EP - 2842

JO - Journal of Immunology

JF - Journal of Immunology

SN - 0022-1767

IS - 10

ER -