Cutting Edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans

Sophie Joly, Stephanie C. Eisenbarth, Alicia K. Olivier, Adam Williams, Daniel H. Kaplan, Suzanne L. Cassel, Richard A. Flavell, Fayyaz S. Sutterwala*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


Nucleotide-binding domain leucine-rich repeat containing receptors (NLRs) are cytosolic receptors that initiate immune responses to sterile and infectious insults to the host. Studies demonstrated that Nlrp3 is critical for the control of Candida albicans infections and in the generation of antifungal Th17 responses. In this article, we show that the NLR family member Nlrp10 also plays a unique role in the control of disseminated C. albicans infection in vivo. Nlrp10-deficient mice had increased susceptibility to disseminated candidiasis, as indicated by decreased survival and increased fungal burdens. In contrast to Nlrp3, Nlrp10 deficiency did not affect innate proinflammatory cytokine production from macrophages and dendritic cells challenged with C. albicans. However, Nlrp10-deficient mice displayed a profound defect in Candida-specific Th1 and Th17 responses. These results demonstrate a novel role for Nlrp10 in the generation of adaptive immune responses to fungal infection.

Original languageEnglish (US)
Pages (from-to)4713-4717
Number of pages5
JournalJournal of Immunology
Issue number10
StatePublished - Nov 15 2012
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Cutting Edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans'. Together they form a unique fingerprint.

Cite this