Cyanine dye conjugates as probes for live cell imaging

Jay R. Carreon, Kelly M. Stewart, Kerry P. Mahon, Stephanie Shin, Shana O. Kelley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations

Abstract

A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging.

Original languageEnglish (US)
Pages (from-to)5182-5185
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume17
Issue number18
DOIs
StatePublished - Sep 15 2007
Externally publishedYes

Keywords

  • Cellular imaging
  • Dyes
  • Fluorescence imaging
  • Peptide conjugate

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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