Cyanine dye conjugates as probes for live cell imaging

Jay R. Carreon; Kelly M. Stewart; Kerry P. Mahon; Stephanie Shin; Shana O. Kelley

doi:10.1016/j.bmcl.2007.06.097

Cyanine dye conjugates as probes for live cell imaging

Jay R. Carreon, Kelly M. Stewart, Kerry P. Mahon, Stephanie Shin, Shana O. Kelley^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging.

Original language	English (US)
Pages (from-to)	5182-5185
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	17
Issue number	18
DOIs	https://doi.org/10.1016/j.bmcl.2007.06.097
State	Published - Sep 15 2007
Externally published	Yes

Keywords

Cellular imaging
Dyes
Fluorescence imaging
Peptide conjugate

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2007.06.097

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title = "Cyanine dye conjugates as probes for live cell imaging",

abstract = "A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging.",

keywords = "Cellular imaging, Dyes, Fluorescence imaging, Peptide conjugate",

author = "Carreon, {Jay R.} and Stewart, {Kelly M.} and Mahon, {Kerry P.} and Stephanie Shin and Kelley, {Shana O.}",

note = "Funding Information: We wish to acknowledge the following sources for support of this work: the Sloan Foundation for a Research Fellowship to S.O.K., the Dreyfus Foundation for a Camille Dreyfus Teacher-Scholar Award to S.O.K., the NSF for a CAREER award to S.O.K and the Beckman Foundation for a Beckman Scholars Fellowship to S.S. ",

year = "2007",

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day = "15",

doi = "10.1016/j.bmcl.2007.06.097",

language = "English (US)",

volume = "17",

pages = "5182--5185",

journal = "Bioorganic and Medicinal Chemistry Letters",

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publisher = "Elsevier Limited",

number = "18",

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TY - JOUR

T1 - Cyanine dye conjugates as probes for live cell imaging

AU - Carreon, Jay R.

AU - Stewart, Kelly M.

AU - Mahon, Kerry P.

AU - Shin, Stephanie

AU - Kelley, Shana O.

N1 - Funding Information: We wish to acknowledge the following sources for support of this work: the Sloan Foundation for a Research Fellowship to S.O.K., the Dreyfus Foundation for a Camille Dreyfus Teacher-Scholar Award to S.O.K., the NSF for a CAREER award to S.O.K and the Beckman Foundation for a Beckman Scholars Fellowship to S.S.

PY - 2007/9/15

Y1 - 2007/9/15

N2 - A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging.

AB - A series of fluorescent compounds suitable for live cell imaging is described. Functionalized forms of four different asymmetric cyanine dyes are reported that are amenable to peptide conjugation. The photophysical properties of the modified dyes and conjugates and the use of the compounds as cellular imaging agents are described. The results obtained indicate that these spectrally versatile compounds, which have absorption and emission profiles spanning the visible spectrum, are useful probes for cellular imaging.

KW - Cellular imaging

KW - Dyes

KW - Fluorescence imaging

KW - Peptide conjugate

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DO - 10.1016/j.bmcl.2007.06.097

M3 - Article

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AN - SCOPUS:34547923688

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EP - 5185

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 18

ER -

Cyanine dye conjugates as probes for live cell imaging

Abstract

Keywords

ASJC Scopus subject areas

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