Cyclic AMP‐Dependent Protein Kinase Activity in Human Brain Across Age

M. J. Schmidt; L. L. Truex; B. Ghetti; A. Routtenberg

doi:10.1111/j.1471-4159.1980.tb12514.x

Cyclic AMP‐Dependent Protein Kinase Activity in Human Brain Across Age

M. J. Schmidt^*, L. L. Truex, B. Ghetti, A. Routtenberg

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Abstract: Cyclic AMP‐dependent protein kinase activity was measured in the cerebral cortex of humans 2 days to 83 years of age and in the cortex of F344 rats 3, 22, or 30 months of age. Protein kinase activity was detected in the human brain, but no age‐related differences in activity were observed in the presence or absence of cyclic AMP. Age differences were also not seen in protein kinase in the rat cerebral cortex. Enzyme activities in rat and human brain were similar.

Original language	English (US)
Pages (from-to)	261-265
Number of pages	5
Journal	Journal of neurochemistry
Volume	35
Issue number	1
DOIs	https://doi.org/10.1111/j.1471-4159.1980.tb12514.x
State	Published - Jul 1980

Keywords

Aging
Cyclic AMP
Development
Human brain
Protein kinase

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Biochemistry

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10.1111/j.1471-4159.1980.tb12514.x

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N2 - Abstract: Cyclic AMP‐dependent protein kinase activity was measured in the cerebral cortex of humans 2 days to 83 years of age and in the cortex of F344 rats 3, 22, or 30 months of age. Protein kinase activity was detected in the human brain, but no age‐related differences in activity were observed in the presence or absence of cyclic AMP. Age differences were also not seen in protein kinase in the rat cerebral cortex. Enzyme activities in rat and human brain were similar.

AB - Abstract: Cyclic AMP‐dependent protein kinase activity was measured in the cerebral cortex of humans 2 days to 83 years of age and in the cortex of F344 rats 3, 22, or 30 months of age. Protein kinase activity was detected in the human brain, but no age‐related differences in activity were observed in the presence or absence of cyclic AMP. Age differences were also not seen in protein kinase in the rat cerebral cortex. Enzyme activities in rat and human brain were similar.

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KW - Cyclic AMP

KW - Development

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KW - Protein kinase

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Cyclic AMP‐Dependent Protein Kinase Activity in Human Brain Across Age

Abstract

Keywords

ASJC Scopus subject areas

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