Cyclic AMP‐Dependent Protein Kinase Activity in Human Brain Across Age

M. J. Schmidt*, L. L. Truex, B. Ghetti, A. Routtenberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Abstract: Cyclic AMP‐dependent protein kinase activity was measured in the cerebral cortex of humans 2 days to 83 years of age and in the cortex of F344 rats 3, 22, or 30 months of age. Protein kinase activity was detected in the human brain, but no age‐related differences in activity were observed in the presence or absence of cyclic AMP. Age differences were also not seen in protein kinase in the rat cerebral cortex. Enzyme activities in rat and human brain were similar.

Original languageEnglish (US)
Pages (from-to)261-265
Number of pages5
JournalJournal of Neurochemistry
Issue number1
StatePublished - Jan 1 1980


  • Aging
  • Cyclic AMP
  • Development
  • Human brain
  • Protein kinase

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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