Cyclooxygenase-2: A therapeutic target in angiogenesis

Miguel A. Iñiguez, Antonio Rodríguez, Olga V. Volpert, Manuel Fresno, Juan Miguel Redondo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

176 Scopus citations

Abstract

Angiogenesis has a role in the pathogenesis of several disorders, including cancer, chronic inflammatory diseases and retinopathies. Recent evidence demonstrates that the production of prostanoids by cyclooxygenase-2 (COX-2) promotes the expression of pro-angiogenic factors. Furthermore, inhibition of COX-2 by non-steroidal anti-inflammatory drugs leads to restricted angiogenesis and downregulated production of pro-angiogenic factors, such as vascular endothelial growth factor and basic fibroblast growth factor. These findings suggest that COX enzymes could be important therapeutic targets in the treatment of pathological angiogenesis.

Original languageEnglish (US)
Pages (from-to)73-78
Number of pages6
JournalTrends in Molecular Medicine
Volume9
Issue number2
DOIs
StatePublished - Feb 1 2003

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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