Cyclophosphamide treatment of primary angiitis of the central nervous system in children: Report of 2 cases

Kathryn J. Bitter, Leon G. Epstein, Hector Melin-Aldana, John G. Curran, Michael L. Miller*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Primary angiitis of the central nervous system (PACNS) is a rare, idiopathic vusculitis diagnosed most frequently in adults. We deserihe 2 children presenting with hemiplegia from PACNS treated with cyclophosphamide. Diagnosis in one child was based on abnormal angiography. Oral, but not intravenous (IV), cyclophosphamide was effective in preventing progressive weakness. The second child had unremarkable angiography, but brain biopsy revealed vasculitis: IV cyclophosphamide prevented further weakness. Both cases highlight the importance of early diagnosis and treatment.

Original languageEnglish (US)
Pages (from-to)2078-2080
Number of pages3
JournalJournal of Rheumatology
Volume33
Issue number10
StatePublished - Oct 1 2006

Keywords

  • Children
  • Cyclophosphamide
  • Primary angiitis

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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