TY - JOUR
T1 - Cyclosporine a inhibits calcemic hormone‐induced bone resorption in vitro
AU - Stewart, Pamela J.
AU - Green, Orville C.
AU - Stern, Paula H.
PY - 1986/6
Y1 - 1986/6
N2 - We have investigated the in vitro effects of cyclosporine (CsA), a potent immunosuppressive agent, on bone resorption induced by calcemic hormones. CsA inhibited parathyroid hormone (PTH), prostaglandin E2, 1,25‐dihydroxy vitamin D3 (1,25(OH)2D3), and osteoclast‐activating factor induced resorption of fetal rat limb bones in a dose‐dependent manner. Established ongoing resorptive activity in bone was also inhibited by CsA. The CsA inhibition of bone resorption could be partially surmounted by higher concentrations of PTH and 1,25(OH)2D3. The inhibitory effects of CsA on limb bone resorption were reversible. Neither protein nor DNA synthesis were inhibited by treatment of limb bones with CsA. Thus, the inhibitory effect of this agent on bone resorption is not a cytotoxic one. These data could suggest that the induction of bone resorption by the calcemic hormones involves an immune cell derived mediator such as a lymphokine.
AB - We have investigated the in vitro effects of cyclosporine (CsA), a potent immunosuppressive agent, on bone resorption induced by calcemic hormones. CsA inhibited parathyroid hormone (PTH), prostaglandin E2, 1,25‐dihydroxy vitamin D3 (1,25(OH)2D3), and osteoclast‐activating factor induced resorption of fetal rat limb bones in a dose‐dependent manner. Established ongoing resorptive activity in bone was also inhibited by CsA. The CsA inhibition of bone resorption could be partially surmounted by higher concentrations of PTH and 1,25(OH)2D3. The inhibitory effects of CsA on limb bone resorption were reversible. Neither protein nor DNA synthesis were inhibited by treatment of limb bones with CsA. Thus, the inhibitory effect of this agent on bone resorption is not a cytotoxic one. These data could suggest that the induction of bone resorption by the calcemic hormones involves an immune cell derived mediator such as a lymphokine.
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U2 - 10.1002/jbmr.5650010307
DO - 10.1002/jbmr.5650010307
M3 - Article
C2 - 3503544
AN - SCOPUS:0022724506
SN - 0884-0431
VL - 1
SP - 285
EP - 291
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
IS - 3
ER -