Cyclosporine a inhibits calcemic hormone‐induced bone resorption in vitro

Pamela J. Stewart*, Orville C. Green, Paula H Stern

*Corresponding author for this work

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

We have investigated the in vitro effects of cyclosporine (CsA), a potent immunosuppressive agent, on bone resorption induced by calcemic hormones. CsA inhibited parathyroid hormone (PTH), prostaglandin E2, 1,25‐dihydroxy vitamin D3 (1,25(OH)2D3), and osteoclast‐activating factor induced resorption of fetal rat limb bones in a dose‐dependent manner. Established ongoing resorptive activity in bone was also inhibited by CsA. The CsA inhibition of bone resorption could be partially surmounted by higher concentrations of PTH and 1,25(OH)2D3. The inhibitory effects of CsA on limb bone resorption were reversible. Neither protein nor DNA synthesis were inhibited by treatment of limb bones with CsA. Thus, the inhibitory effect of this agent on bone resorption is not a cytotoxic one. These data could suggest that the induction of bone resorption by the calcemic hormones involves an immune cell derived mediator such as a lymphokine.

Original languageEnglish (US)
Pages (from-to)285-291
Number of pages7
JournalJournal of Bone and Mineral Research
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1986

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine

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