Cystic fibrosis patients have poor sleep quality despite normal sleep latency and efficiency

Larry Jankelowitz, Kathryn J. Reid, Lisa Wolfe, Joanne Cullina, Phyllis C. Zee, Manu Jain*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


Study objectives: Cystic fibrosis (CF) patients may be predisposed to poor sleep quality due to upper and lower airway abnormalities and impaired gas exchange. Previous sleep investigations of CF patients using single-night polysomnography have reported conflicting results. We hypothesized that sampling sleep for a prolonged period in a patient's normal environment may give a more representative assessment of sleep quality than a single-night polysomnogram, and that impaired sleep quality would correlate with pulmonary disease severity and self-assessed sleep quality. Design: Using wrist actigraphy, we measured sleep quality in clinically stable CF patients and age-matched control subjects. In addition, each CF patient and control subject completed the following three questionnaires: the Epworth sleepiness scale; the Pittsburgh sleep quality index (PSQI); and the Medical Outcomes Study 36-item short form. Results: Twenty CF patients and control subjects were enrolled in the study, and were well-matched for age, sex, and body mass index. The mean (± SD) FEV1 for CF patients was 61.0 ± 20.1% predicted. CF patients and control subjects had similar sleep duration, sleep latency, and sleep efficiency. However, CF patients had higher PSQI scores (6.45 vs 4.55, respectively; p = .04), a higher fragmentation index (FI) [31.72 vs 18.02, respectively; p < 0.001], and less immobile time (88.87 vs 91.89, respectively; p = 0.02). There was a significant correlation of FI with FEV1 and PSQI scores. Conclusions: Stable CF patients have disrupted sleep, and sleep disruption may in part be related to the severity of pulmonary disease. In addition, the PSQI may be useful in detecting CF patients with poor sleep quality.

Original languageEnglish (US)
Pages (from-to)1593-1599
Number of pages7
Issue number5
StatePublished - May 2005


  • Actigraphy
  • Cystic fibrosis
  • Fragmentation
  • Pittsburgh sleep quality index
  • Sleep

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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