Cytogenetic abnormalities in two cases of neuroblastoma

Raulie Lo, Elizabeth Perlman, Anita L. Hawkins, Robert Hayashi, Daniel S. Wechsler, A. Thomas Look, Constance A. Griffin*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Neuroblastomas are common solid tumors in children. We report chromosome analysis of two neuroblastomas, each studied at diagnosis and at recurrence. The first case was a clinical stage D tumor which showed 45,X, -Y, add(1)(p34),der(15)t(Y;15)(q11;p13), and double minutes on cytogenetic analysis at diagnosis. At recurrence, the same structural abnormalities were present along with a homogeneously staining region (hsr) at 8q22, 19p12, or 3p23 in each of three related clones. The hsr were shown to represent amplification of the N-myc gene by in situ hybridization. Cytogenetic analysis of the second tumor, stage D-S, showed 48-54,XX,der(1)add(1)(q41), +2, +7, +7, inv(9), +17, + mar. The lack of demonstrative involvement of 1p or visible evidence of gene amplification has also characterized the limited number of D-S specimens previously described, suggesting that stage D-S neuroblastoma indeed differs from stage D disease at the genetic level.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalCancer Genetics and Cytogenetics
Volume74
Issue number1
DOIs
StatePublished - May 1994

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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