Cytogenetic and Mutational Analyses of Melanocytic Tumors

Pedram Gerami, Klaus J. Busam*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Analyses of genetic and genomic alterations of melanocytic tumors have not only led to a better understanding of the pathogenesis of melanocytic tumors but also created new opportunities for improvements in diagnostic accuracy in distinguishing nevus from melanoma, and more effective treatments for patients affected by melanoma. Cytogenetic tests have emerged as a promising ancillary method for the workup of diagnostically problematic melanocytic tumors with ambiguous light microscopic features. Mutation analysis not only is important in treatment decision making but also can be used for improved diagnostic accuracy, staging, and prognosis.

Original languageEnglish (US)
Pages (from-to)555-566
Number of pages12
JournalDermatologic clinics
Volume30
Issue number4
DOIs
StatePublished - Oct 2012

Keywords

  • Fluorescence in situ hybridization
  • Melanoma
  • Mutation
  • Nevus

ASJC Scopus subject areas

  • Dermatology

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