Cytokine alterations associated with inflammatory bowel disease

S. A. Strong*, C. A. De la Motte

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Patients with inflammatory bowel disease commonly present with clinical symptoms and signs caused by local tissue damage. Mucosal injury originates from dysregulation of intestinal immunity, a complex interplay among varied immune components that include cytokines that help orchestrate inflammation, T-cell differentiation, and immunoregulation. The induction, production, secretion, and function of many cytokines have been characterized. Continued study will enhance understanding of disease pathogenesis, improve differentiation between Crohn's disease and ulcerative colitis, and enable development of more effective medical therapy.

Original languageEnglish (US)
Pages (from-to)22-28
Number of pages7
JournalSeminars in Colon and Rectal Surgery
Volume12
Issue number1
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Gastroenterology
  • Surgery

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