Cytokine changes in thrombotic thrombocytopenic purpura following kidney transplantation

G. W. Burke; R. Cirocco; M. Carreno; V. Pardo; D. Roth; A. Castillo; J. D. Temple; V. Esquenazi; M. Milgrom; J. Miller

Cytokine changes in thrombotic thrombocytopenic purpura following kidney transplantation

G. W. Burke^*, R. Cirocco, M. Carreno, V. Pardo, D. Roth, A. Castillo, J. D. Temple, V. Esquenazi, M. Milgrom, J. Miller

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The occurrence of thrombotic thrombocytopenic purpura (TTP) following kidney transplantation is rare. We report a patient who developed TTP within 36 hours of kidney transplantation. For 5 months preoperatively, serum levels of Interleukin-2 (IL-2) and gamma interferon (IFNG) were markedly elevated. Subsequent to kidney transplantation and steroid administration, thrombocytopenia, with schistocytic anemia and severe neurologic changes (TTP), abruptly occurred. This was associated with a dramatic fall in the levels of IL-2 and gamma-IFN. There was no clinical improvement with plasmapheresis. The patient's serum was not cytotoxic when added with complement to the donor renal vein endothelial cells in vitro. Removal of the allograft corrected the TTP.

Original language	English (US)
Pages (from-to)	47-51
Number of pages	5
Journal	Clinical Transplantation
Volume	7
Issue number	1 I
State	Published - 1993

Keywords

Cytokines
Gamma-interferon
Interleukin 1
Interleukin 2
Interleukin 2 receptor
Kidney transplantation
Thrombocytopenic purpura
Thrombotic

ASJC Scopus subject areas

Transplantation

Cite this

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title = "Cytokine changes in thrombotic thrombocytopenic purpura following kidney transplantation",

abstract = "The occurrence of thrombotic thrombocytopenic purpura (TTP) following kidney transplantation is rare. We report a patient who developed TTP within 36 hours of kidney transplantation. For 5 months preoperatively, serum levels of Interleukin-2 (IL-2) and gamma interferon (IFNG) were markedly elevated. Subsequent to kidney transplantation and steroid administration, thrombocytopenia, with schistocytic anemia and severe neurologic changes (TTP), abruptly occurred. This was associated with a dramatic fall in the levels of IL-2 and gamma-IFN. There was no clinical improvement with plasmapheresis. The patient's serum was not cytotoxic when added with complement to the donor renal vein endothelial cells in vitro. Removal of the allograft corrected the TTP.",

keywords = "Cytokines, Gamma-interferon, Interleukin 1, Interleukin 2, Interleukin 2 receptor, Kidney transplantation, Thrombocytopenic purpura, Thrombotic",

author = "Burke, {G. W.} and R. Cirocco and M. Carreno and V. Pardo and D. Roth and A. Castillo and Temple, {J. D.} and V. Esquenazi and M. Milgrom and J. Miller",

year = "1993",

language = "English (US)",

volume = "7",

pages = "47--51",

journal = "Clinical Transplantation",

issn = "0902-0063",

publisher = "Wiley-Blackwell Publishing Ltd",

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TY - JOUR

T1 - Cytokine changes in thrombotic thrombocytopenic purpura following kidney transplantation

AU - Burke, G. W.

AU - Cirocco, R.

AU - Carreno, M.

AU - Pardo, V.

AU - Roth, D.

AU - Castillo, A.

AU - Temple, J. D.

AU - Esquenazi, V.

AU - Milgrom, M.

AU - Miller, J.

PY - 1993

Y1 - 1993

N2 - The occurrence of thrombotic thrombocytopenic purpura (TTP) following kidney transplantation is rare. We report a patient who developed TTP within 36 hours of kidney transplantation. For 5 months preoperatively, serum levels of Interleukin-2 (IL-2) and gamma interferon (IFNG) were markedly elevated. Subsequent to kidney transplantation and steroid administration, thrombocytopenia, with schistocytic anemia and severe neurologic changes (TTP), abruptly occurred. This was associated with a dramatic fall in the levels of IL-2 and gamma-IFN. There was no clinical improvement with plasmapheresis. The patient's serum was not cytotoxic when added with complement to the donor renal vein endothelial cells in vitro. Removal of the allograft corrected the TTP.

AB - The occurrence of thrombotic thrombocytopenic purpura (TTP) following kidney transplantation is rare. We report a patient who developed TTP within 36 hours of kidney transplantation. For 5 months preoperatively, serum levels of Interleukin-2 (IL-2) and gamma interferon (IFNG) were markedly elevated. Subsequent to kidney transplantation and steroid administration, thrombocytopenia, with schistocytic anemia and severe neurologic changes (TTP), abruptly occurred. This was associated with a dramatic fall in the levels of IL-2 and gamma-IFN. There was no clinical improvement with plasmapheresis. The patient's serum was not cytotoxic when added with complement to the donor renal vein endothelial cells in vitro. Removal of the allograft corrected the TTP.

KW - Cytokines

KW - Gamma-interferon

KW - Interleukin 1

KW - Interleukin 2

KW - Interleukin 2 receptor

KW - Kidney transplantation

KW - Thrombocytopenic purpura

KW - Thrombotic

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M3 - Article

AN - SCOPUS:0027415333

SN - 0902-0063

VL - 7

SP - 47

EP - 51

JO - Clinical Transplantation

JF - Clinical Transplantation

IS - 1 I

ER -

Cytokine changes in thrombotic thrombocytopenic purpura following kidney transplantation

Abstract

Keywords

ASJC Scopus subject areas

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