Cytokine control of inflammation and repair in the pathology of multiple sclerosis

Jane M. Rodgers, Stephen D. Miller

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Cytokines are secreted signaling proteins that play an essential role in propagating and regulating immune responses during experimental autoimmune encephalomyelitis (EAE†), the mouse model of the neurodegenerative, autoimmune disease multiple sclerosis (MS). EAE pathology is driven by a myelin-specific T cell response that is activated in the periphery and mediates the destruction of myelin upon T cell infiltration into the central nervous system (CNS). Cytokines provide cell signals both in the immune and CNS compartment, but interestingly, some have detrimental effects in the immune compartment while having beneficial effects in the CNS compartment. The complex nature of these signals will be reviewed.

Original languageEnglish (US)
Pages (from-to)447-468
Number of pages22
JournalYale Journal of Biology and Medicine
Volume85
Issue number4
StatePublished - Dec 2012

Keywords

  • Cytokines
  • Experimental autoimmune encephalomyelitis
  • Multiple sclerosis
  • Neuroinflammation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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