Cytokine networks in the infected lung

Urvashi Bhan, Matthew D. Cornicelli, Theodore J. Standiford*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

The generation of an innate immune response is essential for rapid clearance of microbes from the respiratory tract, whereas acquired immunity is required for the generation of cellular immunity neccessary for the killing of certain intracellular pathogens and the development of immunological memory. Cytokines play an integral role in host defense by serving as leukocyte chemoattractants, leukocyte-activating factors or afferent signals in the induction or regulation of other effector molecules. This review assesses the contribution of cytokine networks to the generation of antimicrobial host defenses in the lung, with an emphasis on cytokines/cytokine networks that are instrumental in innate antibacterial responses, including mucosal immunity, and also introduces networks that instruct the development of adaptive immunity.

Original languageEnglish (US)
Pages (from-to)739-752
Number of pages14
JournalExpert Review of Respiratory Medicine
Volume2
Issue number6
DOIs
StatePublished - 2008
Externally publishedYes

Keywords

  • Acquired immunity
  • Chemokine
  • Cytokine
  • Host defense
  • Immunotherapy
  • Innate immunity
  • Pneumonia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine
  • Public Health, Environmental and Occupational Health

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