Cytokine production by mast cells and basophils

Stephen J. Galli*, John R. Gordon, Barry K. Wershil

*Corresponding author for this work

Research output: Contribution to journalArticle

307 Scopus citations

Abstract

Mast cells and/or basophils have been implicated in the expression of a wide variety of biological responses, including immediate hypersensitivity reactions, host responses to parasites and neoplasms, angiogenesis, tissue remodeling, and immunologically non-specific inflammatory and fibrotic conditions. Recent findings suggest that an important mechanism by which mast cells influence such biological responses is through the production of a broad panel of multifunctional cytokines. In contrast, the extent to which basophils can produce cytokines is uncertain.

Original languageEnglish (US)
Pages (from-to)865-873
Number of pages9
JournalCurrent Opinion in Immunology
Volume3
Issue number6
DOIs
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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