Cytokine therapy of cutaneous T-cell lymphoma: Interferons, interleukin-12, and interleukin-2

Alain H. Rook*, Timothy M. Kuzel, Elise A. Olsen

*Corresponding author for this work

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

It is well accepted that cutaneous T-cell lymphomas (CTCL), including mycosis fungoides and Sézary syndrome, represent lymphomas that are highly responsive to immune modifying agents. Furthermore, the recent emphasis on the use of cytokine-related therapeutics is based upon the exceedingly important role of the host immune response in effecting progression of disease. In this article we discuss the data that support the importance of the host immune response in the control of progression of CTCL and the role that cytokine therapy has in supporting the host immune response and the effects of this approach to induce regression of skin and systemic disease.

Original languageEnglish (US)
Pages (from-to)1435-1448
Number of pages14
JournalHematology/Oncology Clinics of North America
Volume17
Issue number6
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Hematology
  • Oncology

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