Cytokines in allergic bronchopulmonary aspergillosis

P. S. Murali; P. A. Greenberger; V. P. Kurup

doi:10.1016/S0889-8561(05)70029-1

Cytokines in allergic bronchopulmonary aspergillosis

P. S. Murali^*, P. A. Greenberger, V. P. Kurup

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

The role of cytokines in the regulation of immune responses and the pathogenesis of ABPA is not fully understood. The Aspergillus-specific circulation IgE and significant eosinophilia led to the assumption that ABPA is a Th2-mediated disease, which was proved by the enhanced presence of interleukin-4 (IL-4) and IL-5 in these patients. Administration of anti-IL-4 and anti-IL-5 antibodies down-regulated the Th2 responses in murine models of APBA. This conclusion was further supported by studies with the gene knockout murine model of ABPA. Understanding the role of cytokines in ABPA and in murine models may shed light on the immunopathogenesis of the disease, which may lead to definitive diagnosis and better patient care.

Original language	English (US)
Pages (from-to)	681-694
Number of pages	14
Journal	Immunology and Allergy Clinics of North America
Volume	18
Issue number	3
DOIs	https://doi.org/10.1016/S0889-8561(05)70029-1
State	Published - 1998

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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abstract = "The role of cytokines in the regulation of immune responses and the pathogenesis of ABPA is not fully understood. The Aspergillus-specific circulation IgE and significant eosinophilia led to the assumption that ABPA is a Th2-mediated disease, which was proved by the enhanced presence of interleukin-4 (IL-4) and IL-5 in these patients. Administration of anti-IL-4 and anti-IL-5 antibodies down-regulated the Th2 responses in murine models of APBA. This conclusion was further supported by studies with the gene knockout murine model of ABPA. Understanding the role of cytokines in ABPA and in murine models may shed light on the immunopathogenesis of the disease, which may lead to definitive diagnosis and better patient care.",

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AU - Greenberger, P. A.

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AB - The role of cytokines in the regulation of immune responses and the pathogenesis of ABPA is not fully understood. The Aspergillus-specific circulation IgE and significant eosinophilia led to the assumption that ABPA is a Th2-mediated disease, which was proved by the enhanced presence of interleukin-4 (IL-4) and IL-5 in these patients. Administration of anti-IL-4 and anti-IL-5 antibodies down-regulated the Th2 responses in murine models of APBA. This conclusion was further supported by studies with the gene knockout murine model of ABPA. Understanding the role of cytokines in ABPA and in murine models may shed light on the immunopathogenesis of the disease, which may lead to definitive diagnosis and better patient care.

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Cytokines in allergic bronchopulmonary aspergillosis

Abstract

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