Cytologic and histologic findings in multiple renal hybrid oncocytic tumors in a patients with Birt-Hogg-Dubé syndrome: A case report

Brian P. Adley*, Kristian T. Schafernak, Anjana V Yeldandi, Ximing J Yang, Ritu Nayar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Background: Birt-Hogg-Dubé (BHD) syndrome is a rare autosomal dominant neoplastic syndrome characterized by multiple skin lesions, lung cysts and renal tumors. A variety of histologic types of renal tumors have been reported, including clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe RCC, oncocytoma and a recently described hybrid oncocytic tumor, which is thought to be highly associated with BHD. Case: We report a case of a 48-year-old woman with BHD who initially presented to our institution with spontaneous pneumothorax and was found to have multiple lung cysts and renal tumors on computed tomography. We describe the fine needle aspiration findings of one of the renal tumors, which was suggestive of so-called hybrid oncocytic tumor. We also describe the gross and histologic findings of the multiple kidney tumors that the patient subsequently had excised. Conclusion: When multiple kidney tumors from a single patient appear oncycytic on fine needle aspiration, especially when focal clear cells are present, the possibility of oncocytomas and hybrid tumors associated with BHD must be entertained.

Original languageEnglish (US)
Pages (from-to)584-588
Number of pages5
JournalActa Cytologica
Volume50
Issue number5
DOIs
StatePublished - Jan 1 2006

Keywords

  • Birt-Hogg-Dubé protein
  • Human; hybrid oncocytic tumor
  • Kidney neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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