Cytologic features of neoplastic lesions in endocervical glands

K. P. Siziopikou, H. H. Wang, G. Abu-Jawdeh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Cytologic criteria for classifying atypical endocervical cells on Pap smears are poorly defined. In this study we evaluated cytologic parameters that are useful in predicting the presence of neoplastic lesions (NL) and those that help distinguished squamous intraepithelial lesion (SIL) from glandular neoplastic lesions. The recently proposed Bethesda System (TBS) terminology for reporting atypical glandular cells of undetermined significance (AGUS) was also evaluated for its significance on patient management. Sixteen cases of biopsy-proven endocervical glandular NL that had cytologic smeary available for review were included. Thirty-five smears with atypical endocervical cells and follow-up biopsies showing benign/reactive change (n = 22) and SIL involving glands (n = 13) were reviewed for comparison. Our results show that squamous NL often coexist with glandular NL. The presence of rosettes, hyperchromasia, and increased N/C ratio is useful in distinguishing NL from benign/reactive conditions. Architectural features are helpful in distinguishing SIL from glandular NL. While a haphazard arrangement is more often seen with SIL, glandular NL are more likely to maintain polarity and to show glandular rosettes. Using TBS criteria, a conservative management seems justified in patients with AGUS- favor reactive and AGUS diagnosis on Pap smear, and colposcopy is indicated for patients with AGUS-favor NL.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalDiagnostic cytopathology
Issue number1
StatePublished - Jul 1997


  • Atypia
  • Cervix
  • Cytology
  • Endocervical glands
  • Glandular lesions
  • Intraepithelial neoplasia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology


Dive into the research topics of 'Cytologic features of neoplastic lesions in endocervical glands'. Together they form a unique fingerprint.

Cite this