Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel

Daniel N. Johnson, Mine Onenerk, Jeffrey F. Krane, Esther Diana Rossi, Zubair Baloch, Güliz Barkan, Massimo Bongiovanni, Fabiano Callegari, Sule Canberk, Glen Dixon, Andrew Field, Christopher C. Griffith, Nirag Jhala, Sara Jiang, Daniel Kurtycz, Lester Layfield, Oscar Lin, Zahra Maleki, Miguel Perez-Machado, Marc PusztaszeriPhilippe Vielh, He Wang, Matthew A. Zarka, William C. Faquin*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Fine needle aspiration (FNA) is commonly used for the preoperative evaluation of salivary gland tumors. Tumor grade is a key factor influencing clinical management of salivary gland carcinomas (SGCs). To assess the ability to grade nonbasaloid SGCs in FNA specimens, an international panel of cytopathologists convened to review and score SGC cases. Methods: The study cohort included 61 cases of primary SGC from the pathology archives of 3 tertiary medical centers. Cases from 2005 to 2016 were selected, scanned, and digitized. Nineteen cytopathologists blinded to the histologic diagnosis reviewed the digitized cytology slides and graded them as low, high, or indeterminate. The panelists' results were then compared to the tumor grades based on histopathologic examination of the corresponding resection specimens. Results: All but 2 of the 19 (89.5%) expert panelists review more than 20 salivary gland FNAs per year; 16 (84.2%) of the panelists work at academic medical centers, and 13 (68.4%) have more than 10 years' experience. Participants had an overall accuracy of 89.4% in the grading of SGC cases, with 90.2% and 88.3% for low- and high-grade SGC, respectively. Acinic cell carcinoma and mucoepidermoid carcinoma had the highest degree of accuracy, while epithelial-myoepithelial carcinoma and salivary duct carcinoma had the lowest degree of accuracy. As expected, the intermediate-grade SGC cases showed the greatest variability (high-grade, 42.1%; low-grade, 37.5%, indeterminate, 20.4%). Conclusion: This study confirms the high accuracy of cytomorphologic grading of primary SGC by FNA as low- or high-grade. However, caution should be exercised when a grade cannot be confidently assigned.

Original languageEnglish (US)
Pages (from-to)392-402
Number of pages11
JournalCancer Cytopathology
Volume128
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • FNA
  • Milan system
  • cancer
  • cytology
  • grading
  • salivary gland

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Johnson, D. N., Onenerk, M., Krane, J. F., Rossi, E. D., Baloch, Z., Barkan, G., Bongiovanni, M., Callegari, F., Canberk, S., Dixon, G., Field, A., Griffith, C. C., Jhala, N., Jiang, S., Kurtycz, D., Layfield, L., Lin, O., Maleki, Z., Perez-Machado, M., ... Faquin, W. C. (2020). Cytologic grading of primary malignant salivary gland tumors: A blinded review by an international panel. Cancer Cytopathology, 128(6), 392-402. https://doi.org/10.1002/cncy.22271