Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases

Ian A. Gelarden*, Lucy Fu, Kai Lee Yap, Aida I. Richardson, Pauline M. Chou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.

Original languageEnglish (US)
Pages (from-to)E163-E169
JournalDiagnostic cytopathology
Volume50
Issue number6
DOIs
StatePublished - Jun 2022

Keywords

  • EWSR1
  • POU5F1
  • core needle biopsy
  • cytology
  • myoepithelial tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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