Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases

Ian A. Gelarden; Lucy Fu; Kai Lee Yap; Aida I. Richardson; Pauline M. Chou

doi:10.1002/dc.24941

Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases

Ian A. Gelarden^*, Lucy Fu, Kai Lee Yap, Aida I. Richardson, Pauline M. Chou

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

Abstract

Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.

Original language	English (US)
Pages (from-to)	E163-E169
Journal	Diagnostic cytopathology
Volume	50
Issue number	6
DOIs	https://doi.org/10.1002/dc.24941
State	Published - Jun 2022

Funding

The authors thank Jenna Holcomb for assistance with Table?1.

Keywords

EWSR1
POU5F1
core needle biopsy
cytology
myoepithelial tumor

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

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10.1002/dc.24941

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@article{ae9fb3f7c8c34eb4af23050ffa21fc7b,

title = "Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases",

abstract = "Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.",

keywords = "EWSR1, POU5F1, core needle biopsy, cytology, myoepithelial tumor",

author = "Gelarden, {Ian A.} and Lucy Fu and Yap, {Kai Lee} and Richardson, {Aida I.} and Chou, {Pauline M.}",

note = "Funding Information: The authors thank Jenna Holcomb for assistance with Table?1. Publisher Copyright: {\textcopyright} 2022 Wiley Periodicals LLC.",

year = "2022",

month = jun,

doi = "10.1002/dc.24941",

language = "English (US)",

volume = "50",

pages = "E163--E169",

journal = "Diagnostic cytopathology",

issn = "8755-1039",

publisher = "John Wiley and Sons Inc.",

number = "6",

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TY - JOUR

T1 - Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions

T2 - A report of two cases

AU - Gelarden, Ian A.

AU - Fu, Lucy

AU - Yap, Kai Lee

AU - Richardson, Aida I.

AU - Chou, Pauline M.

PY - 2022/6

Y1 - 2022/6

N2 - Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.

AB - Myoepithelial tumors (MET) constitute a group of neoplasms with a variety of morphologic, immunophenotypic, and molecular features. Approximately half of MET of soft tissue harbor EWSR1 gene rearrangements with a subset showing EWSR1-POU5F1 fusions and demonstrating distinctive tendency towards aggressive behavior in children. Histologically, EWSR1-POU5F1-positive MET typically show clear-cell morphology with malignant features including marked pleomorphism and atypical mitotic figures. The cytomorphology of these tumors has not been well characterized. Reported here are the cytomorphologic features of two cases of EWSR1-POUF1-positive MET with histology correlation.

KW - EWSR1

KW - POU5F1

KW - core needle biopsy

KW - cytology

KW - myoepithelial tumor

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ER -

Cytology-histology correlation of myoepithelial tumors harboring EWSR1-POU5F1 fusions: A report of two cases

Abstract

Funding

Keywords

ASJC Scopus subject areas

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