Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS

T. Mazzulli; R. H. Rubin; M. J. Ferraro; R. T. D'Aquila; S. A. Doveikis; B. R. Smith; T. H. The; M. S. Hirsch

doi:10.1128/jcm.31.10.2824-2827.1993

Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS

T. Mazzulli, R. H. Rubin, M. J. Ferraro, R. T. D'Aquila, S. A. Doveikis, B. R. Smith, T. H. The, M. S. Hirsch^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

Research output: Contribution to journal › Comment/debate › peer-review

78 Scopus citations

Abstract

We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.

Original language	English (US)
Pages (from-to)	2824-2827
Number of pages	4
Journal	Journal of clinical microbiology
Volume	31
Issue number	10
DOIs	https://doi.org/10.1128/jcm.31.10.2824-2827.1993
State	Published - 1993

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/jcm.31.10.2824-2827.1993

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title = "Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS",

abstract = "We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.",

author = "T. Mazzulli and Rubin, {R. H.} and Ferraro, {M. J.} and D'Aquila, {R. T.} and Doveikis, {S. A.} and Smith, {B. R.} and The, {T. H.} and Hirsch, {M. S.}",

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doi = "10.1128/jcm.31.10.2824-2827.1993",

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T1 - Cytomegalovirus antigenemia

T2 - Clinical correlations in transplant recipients and in persons with AIDS

AU - Mazzulli, T.

AU - Rubin, R. H.

AU - Ferraro, M. J.

AU - D'Aquila, R. T.

AU - Doveikis, S. A.

AU - Smith, B. R.

AU - The, T. H.

AU - Hirsch, M. S.

PY - 1993

Y1 - 1993

N2 - We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.

AB - We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.

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DO - 10.1128/jcm.31.10.2824-2827.1993

M3 - Comment/debate

C2 - 8253997

AN - SCOPUS:0027360379

SN - 0095-1137

VL - 31

SP - 2824

EP - 2827

JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

IS - 10

ER -

Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS

Abstract

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