Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS

T. Mazzulli, R. H. Rubin, M. J. Ferraro, R. T. D'Aquila, S. A. Doveikis, B. R. Smith, T. H. The, M. S. Hirsch*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

72 Scopus citations

Abstract

We evaluated a rapid immunoperoxidase technique for the detection of cytomegalovirus (CMV) antigenemia in peripheral blood neutrophils of 56 transplant recipients (117 specimens) and 36 persons with AIDS (59 specimens). Antigenemia was 92% sensitive and 98% specific for the detection of clinical CMV infection in transplant recipients and 100% sensitive and 86% specific in persons with AIDS. Overall, CMV antigenemia was a more rapid and sensitive method for the detection of clinical CMV infection than either shell vial culture or conventional tube culture of blood.

Original languageEnglish (US)
Pages (from-to)2824-2827
Number of pages4
JournalJournal of clinical microbiology
Volume31
Issue number10
DOIs
StatePublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)

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    Mazzulli, T., Rubin, R. H., Ferraro, M. J., D'Aquila, R. T., Doveikis, S. A., Smith, B. R., The, T. H., & Hirsch, M. S. (1993). Cytomegalovirus antigenemia: Clinical correlations in transplant recipients and in persons with AIDS. Journal of clinical microbiology, 31(10), 2824-2827. https://doi.org/10.1128/jcm.31.10.2824-2827.1993