Cytomorphology of intraductal oncocytic papillary neoplasm of the liver

Matthew F. Jurczyk, Bing Zhu, Celina Villa, Denise DeFrias, Xiaoqi Lin*

*Corresponding author for this work

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We describe the first cytology case report of an intraductal oncocytic papillary neoplasm (IOPN) of the liver. A 51-year-old male presented with recurrent cholangitis. Magnetic resonance imaging and endoscopic retrograde cholangiopancreatogram revealed a 1.1 x 0.9 cm polypoid lesion within the left intrahepatic bile duct. Fine-needle aspiration and needle core biopsy (NCB) revealed nests, 3-dimensional or papillary clusters of columnar or cuboidal cells with loss of polarity. The nuclei were uniform with even chromatin, and cytoplasm was granular or vacuolated. No mitosis or necrosis was seen. The cytologic and histologic diagnosis was "consistent with Intraductal Oncocytic Papillary Neoplasm (IOPN), intermediate grade (borderline)." The patient then underwent a left lateral liver segmentectomy. Microscopic examination showed histology similar to the NCB with no stromal invasion identified. Hepatic IOPN poses a diagnostic challenge due to its broad differential diagnoses. Both malignant and non-malignant IOPNs may present with similar clinical symptoms, pathology, histology, cytomorphology, and immunohistochemistry. Hepatic IOPN should be excised as it is a precursor lesion of adenocarcinoma.

Original languageEnglish (US)
Pages (from-to)895-898
Number of pages4
JournalDiagnostic Cytopathology
Volume42
Issue number10
DOIs
StatePublished - Jan 1 2014

Fingerprint

Liver Neoplasms
Large-Core Needle Biopsy
Liver
Histology
Intrahepatic Bile Ducts
Neoplasms
Clinical Pathology
Cholangitis
Segmental Mastectomy
Fine Needle Biopsy
Mitosis
Chromatin
Cell Biology
Cytoplasm
Adenocarcinoma
Differential Diagnosis
Necrosis
Immunohistochemistry
Magnetic Resonance Imaging

Keywords

  • Cytomorphology
  • Fine-needle aspiration
  • Intraductal oncocytic papillary neoplasm
  • Liver
  • Needle core biopsy

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

Cite this

Jurczyk, Matthew F. ; Zhu, Bing ; Villa, Celina ; DeFrias, Denise ; Lin, Xiaoqi. / Cytomorphology of intraductal oncocytic papillary neoplasm of the liver. In: Diagnostic Cytopathology. 2014 ; Vol. 42, No. 10. pp. 895-898.
@article{58758d395c2b4a8c8e4d126a62d5707e,
title = "Cytomorphology of intraductal oncocytic papillary neoplasm of the liver",
abstract = "We describe the first cytology case report of an intraductal oncocytic papillary neoplasm (IOPN) of the liver. A 51-year-old male presented with recurrent cholangitis. Magnetic resonance imaging and endoscopic retrograde cholangiopancreatogram revealed a 1.1 x 0.9 cm polypoid lesion within the left intrahepatic bile duct. Fine-needle aspiration and needle core biopsy (NCB) revealed nests, 3-dimensional or papillary clusters of columnar or cuboidal cells with loss of polarity. The nuclei were uniform with even chromatin, and cytoplasm was granular or vacuolated. No mitosis or necrosis was seen. The cytologic and histologic diagnosis was {"}consistent with Intraductal Oncocytic Papillary Neoplasm (IOPN), intermediate grade (borderline).{"} The patient then underwent a left lateral liver segmentectomy. Microscopic examination showed histology similar to the NCB with no stromal invasion identified. Hepatic IOPN poses a diagnostic challenge due to its broad differential diagnoses. Both malignant and non-malignant IOPNs may present with similar clinical symptoms, pathology, histology, cytomorphology, and immunohistochemistry. Hepatic IOPN should be excised as it is a precursor lesion of adenocarcinoma.",
keywords = "Cytomorphology, Fine-needle aspiration, Intraductal oncocytic papillary neoplasm, Liver, Needle core biopsy",
author = "Jurczyk, {Matthew F.} and Bing Zhu and Celina Villa and Denise DeFrias and Xiaoqi Lin",
year = "2014",
month = "1",
day = "1",
doi = "10.1002/dc.23073",
language = "English (US)",
volume = "42",
pages = "895--898",
journal = "Diagnostic Cytopathology",
issn = "8755-1039",
publisher = "Wiley-Liss Inc.",
number = "10",

}

Cytomorphology of intraductal oncocytic papillary neoplasm of the liver. / Jurczyk, Matthew F.; Zhu, Bing; Villa, Celina; DeFrias, Denise; Lin, Xiaoqi.

In: Diagnostic Cytopathology, Vol. 42, No. 10, 01.01.2014, p. 895-898.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Cytomorphology of intraductal oncocytic papillary neoplasm of the liver

AU - Jurczyk, Matthew F.

AU - Zhu, Bing

AU - Villa, Celina

AU - DeFrias, Denise

AU - Lin, Xiaoqi

PY - 2014/1/1

Y1 - 2014/1/1

N2 - We describe the first cytology case report of an intraductal oncocytic papillary neoplasm (IOPN) of the liver. A 51-year-old male presented with recurrent cholangitis. Magnetic resonance imaging and endoscopic retrograde cholangiopancreatogram revealed a 1.1 x 0.9 cm polypoid lesion within the left intrahepatic bile duct. Fine-needle aspiration and needle core biopsy (NCB) revealed nests, 3-dimensional or papillary clusters of columnar or cuboidal cells with loss of polarity. The nuclei were uniform with even chromatin, and cytoplasm was granular or vacuolated. No mitosis or necrosis was seen. The cytologic and histologic diagnosis was "consistent with Intraductal Oncocytic Papillary Neoplasm (IOPN), intermediate grade (borderline)." The patient then underwent a left lateral liver segmentectomy. Microscopic examination showed histology similar to the NCB with no stromal invasion identified. Hepatic IOPN poses a diagnostic challenge due to its broad differential diagnoses. Both malignant and non-malignant IOPNs may present with similar clinical symptoms, pathology, histology, cytomorphology, and immunohistochemistry. Hepatic IOPN should be excised as it is a precursor lesion of adenocarcinoma.

AB - We describe the first cytology case report of an intraductal oncocytic papillary neoplasm (IOPN) of the liver. A 51-year-old male presented with recurrent cholangitis. Magnetic resonance imaging and endoscopic retrograde cholangiopancreatogram revealed a 1.1 x 0.9 cm polypoid lesion within the left intrahepatic bile duct. Fine-needle aspiration and needle core biopsy (NCB) revealed nests, 3-dimensional or papillary clusters of columnar or cuboidal cells with loss of polarity. The nuclei were uniform with even chromatin, and cytoplasm was granular or vacuolated. No mitosis or necrosis was seen. The cytologic and histologic diagnosis was "consistent with Intraductal Oncocytic Papillary Neoplasm (IOPN), intermediate grade (borderline)." The patient then underwent a left lateral liver segmentectomy. Microscopic examination showed histology similar to the NCB with no stromal invasion identified. Hepatic IOPN poses a diagnostic challenge due to its broad differential diagnoses. Both malignant and non-malignant IOPNs may present with similar clinical symptoms, pathology, histology, cytomorphology, and immunohistochemistry. Hepatic IOPN should be excised as it is a precursor lesion of adenocarcinoma.

KW - Cytomorphology

KW - Fine-needle aspiration

KW - Intraductal oncocytic papillary neoplasm

KW - Liver

KW - Needle core biopsy

UR - http://www.scopus.com/inward/record.url?scp=84908071496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84908071496&partnerID=8YFLogxK

U2 - 10.1002/dc.23073

DO - 10.1002/dc.23073

M3 - Article

C2 - 24264957

AN - SCOPUS:84908071496

VL - 42

SP - 895

EP - 898

JO - Diagnostic Cytopathology

JF - Diagnostic Cytopathology

SN - 8755-1039

IS - 10

ER -