TY - JOUR
T1 - Cytotoxic Antibody Complicating Platelet Support in Acute Leukemia
T2 - Response to Chemotherapy
AU - Green, David
AU - Tiro, Aurelio
AU - Basiliere, James
AU - Mittal, Kamal K.
PY - 1976/8
Y1 - 1976/8
N2 - Lymphocytotoxic or thrombocytolytic antibodies were detected in 11 of 25 thrombocytopenic patients receiving repeated platelet transfusions. Platelet survival times were reduced in these patients (half-life [T/2], 32 hours) as compared to patients without antibody (T/2, 51 hours, P <.05). In one woman with acute myeloblastic leukemia and a potent platelet antibody, combination chemotherapy resulted in a profound decrease in circulating γ globulin and concurrent disappearance of the cytotoxic antibody. The survival of transfused platelets in this patient was dramatically improved, and bleeding was controlled.
AB - Lymphocytotoxic or thrombocytolytic antibodies were detected in 11 of 25 thrombocytopenic patients receiving repeated platelet transfusions. Platelet survival times were reduced in these patients (half-life [T/2], 32 hours) as compared to patients without antibody (T/2, 51 hours, P <.05). In one woman with acute myeloblastic leukemia and a potent platelet antibody, combination chemotherapy resulted in a profound decrease in circulating γ globulin and concurrent disappearance of the cytotoxic antibody. The survival of transfused platelets in this patient was dramatically improved, and bleeding was controlled.
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U2 - 10.1001/jama.1976.03270100044027
DO - 10.1001/jama.1976.03270100044027
M3 - Article
C2 - 1067454
AN - SCOPUS:0017318698
SN - 0098-7484
VL - 236
SP - 1044
EP - 1046
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 9
ER -