Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas

Alan M. Krensky

doi:10.1007/BF02918499

Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas

Alan M. Krensky^*

^*Corresponding author for this work

Office of Finance and Administration

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the γ,δ T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by γ,δ T cells.

Original language	English (US)
Pages (from-to)	91-97
Number of pages	7
Journal	Immunologic Research
Volume	15
Issue number	2
DOIs	https://doi.org/10.1007/BF02918499
State	Published - Jun 1996

Keywords

B cell lymphoma (non-Hodgkin's)
Burkitt's lymphoma
Cytotoxic T lymphocytes
Heat shock proteins
Immunotherapy
Tumor
γδ T cell receptor

ASJC Scopus subject areas

Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02918499

Cite this

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title = "Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas",

abstract = "Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the γ,δ T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by γ,δ T cells.",

keywords = "B cell lymphoma (non-Hodgkin's), Burkitt's lymphoma, Cytotoxic T lymphocytes, Heat shock proteins, Immunotherapy, Tumor, γδ T cell receptor",

author = "Krensky, {Alan M.}",

year = "1996",

month = jun,

doi = "10.1007/BF02918499",

language = "English (US)",

volume = "15",

pages = "91--97",

journal = "Immunologic Research",

issn = "0257-277X",

publisher = "Humana Press",

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T1 - Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas

AU - Krensky, Alan M.

PY - 1996/6

Y1 - 1996/6

N2 - Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the γ,δ T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by γ,δ T cells.

AB - Human cytolytic T lymphocytes specific for autologous Burkitt's lymphoma express the γ,δ T cell receptor and recognize immunoglobulin idiotype in an MHC-unrestricted manner. Antibodies against a member of the heat shock protein 70 family inhibit this specific cytotoxicity, implicating these molecules in tumor recognition and antigen presentation. Such data is relevant to the design of novel immunotherapies for cancer and provides new insights into target recognition by γ,δ T cells.

KW - B cell lymphoma (non-Hodgkin's)

KW - Burkitt's lymphoma

KW - Cytotoxic T lymphocytes

KW - Heat shock proteins

KW - Immunotherapy

KW - Tumor

KW - γδ T cell receptor

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U2 - 10.1007/BF02918499

DO - 10.1007/BF02918499

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JO - Immunologic Research

JF - Immunologic Research

IS - 2

ER -

Cytotoxic T lymphocyte recognition of non-Hodgkin's B cell lymphomas

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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