Cytotoxic T lymphocytes specific for self tumor immunoglobulin express T cell receptor δ chain

A. Wright, J. E. Lee, M. P. Link, S. D. Smith, W. Carroll, R. Levy, C. Clayberger, A. M. Krensky

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

CTL are thought to play a role in the elimination of transformed cells in vivo. The effectiveness of such CTL is in part dependent on recognition of tumor specific antigens. Among the best characterized tumor-specific antigens are the unique or idiotypic determinants on the Ig of B cell lymphomas. Here we describe the generation and properties of human CTL specific for the idiotype on autologous B cell tumors. These cells are CD3+, CD4-, CD8- and express the δ chain of the TCR. Such cells may prove useful in tumor-specific adoptive therapy.

Original languageEnglish (US)
Pages (from-to)1557-1564
Number of pages8
JournalJournal of Experimental Medicine
Volume169
Issue number5
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Medicine(all)

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