Cytotoxic triterpenoid saponins from the roots of Cephalaria gigantea

Nino Tabatadze, Riad Elias*, Robert Faure, Pascal Gerkens, Marie Claire De Pauw-Gillet, Ether Kemertelidze, Aun Chea, Evelyne Ollivier

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

Three new oleanane-type saponins, giganteosides L (1), M (2) and N (3) along with eight known ones were isolated from the roots of Cephalaria gigantea. Their structures were established as 3-O-[β-D-galactopyranosyl-(1→2)- β-D-glucuronopyranosyl]-28-O-[β-D-glucopyranosyl-(1→6) -β-D-glucopyranosyl]-oleanolic acid, 3-O-[β-D-galactopyranosyl- (1→2)-β-D-glucuronopyranosyl]-28-O-[β-D-glucopyranosyl-(1→6) -β-D-glucopyranosyl]-hederagenin, 3-O-[α-L-rhamnopyranosyl-(1→2) -β-D-glucuronopyranosyl]-28-O-[β-D-glucopyranosyl-(1→6) -β-D-glucopyranosyl]-hederagenin, respectively, by means of spectroscopic methods (1D and 2D NMR, HR-ESI-MS). Cytotoxic activity of monodesmosides was investigated in vitro using three cancer cell lines, namely, human non pigmented melanoma MEL-5 and human leukemia HL-60. Giganteosides D (4) and E (5) showed antiproliferative effect on human cell lines with IC50 values in the range 3.15-7.5 μM.

Original languageEnglish (US)
Pages (from-to)102-105
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Volume55
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Cephalaria gigantea
  • Cytotoxic activity
  • Dipsacaceae
  • Giganteoside
  • Oleanane-type saponin

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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