Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application

Dong Hyun Kim; Se Ho Lee; Kyoung Nam Kim; Kwang Mahn Kim; In Bo Shim; Yong Keun Lee

doi:10.1016/j.jmmm.2005.02.078

Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application

Dong Hyun Kim, Se Ho Lee, Kyoung Nam Kim, Kwang Mahn Kim, In Bo Shim, Yong Keun Lee^*

^*Corresponding author for this work

Radiology

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

We investigated the cytotoxicity of the prepared various ferrites (Fe-, Li-, Ni/Zn/Cu-, Ba-, Sr-, Co-, Co/Ni-ferrites) using MTT assay as well as agar diffusion method. Their cytotoxicity was compared with that of alginate-encapsulated ferrites. In the MTT assay, Fe₃O₄ and SrFe₁₂O₁₉ ferrite showed the highest cell viability of 90%. Alginate-encapsulated Ba-ferrite was ranked mildly cytotoxic, whereas their ferrite particles were ranked cytotoxic.

Original language	English (US)
Pages (from-to)	287-292
Number of pages	6
Journal	Journal of Magnetism and Magnetic Materials
Volume	293
Issue number	1
DOIs	https://doi.org/10.1016/j.jmmm.2005.02.078
State	Published - May 1 2005

Keywords

Agar overlay assay
Biocompatibility
Co/Ni ferrite
Cobalt ferrite
Cytotoxicity
Ferrite
Hyperthermia
MTT assay
Magnetite
SrFeO ferrite
Toxicity

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1016/j.jmmm.2005.02.078

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title = "Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application",

abstract = "We investigated the cytotoxicity of the prepared various ferrites (Fe-, Li-, Ni/Zn/Cu-, Ba-, Sr-, Co-, Co/Ni-ferrites) using MTT assay as well as agar diffusion method. Their cytotoxicity was compared with that of alginate-encapsulated ferrites. In the MTT assay, Fe3O4 and SrFe12O19 ferrite showed the highest cell viability of 90%. Alginate-encapsulated Ba-ferrite was ranked mildly cytotoxic, whereas their ferrite particles were ranked cytotoxic.",

keywords = "Agar overlay assay, Biocompatibility, Co/Ni ferrite, Cobalt ferrite, Cytotoxicity, Ferrite, Hyperthermia, MTT assay, Magnetite, SrFeO ferrite, Toxicity",

author = "Kim, {Dong Hyun} and Lee, {Se Ho} and Kim, {Kyoung Nam} and Kim, {Kwang Mahn} and Shim, {In Bo} and Lee, {Yong Keun}",

note = "Funding Information: This work was supported by Grant No. R01-2001-000-00157 from the Basic Research Program of the Korea Science & Engineering Foundation. ",

year = "2005",

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T1 - Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application

AU - Kim, Dong Hyun

AU - Lee, Se Ho

AU - Kim, Kyoung Nam

AU - Kim, Kwang Mahn

AU - Shim, In Bo

AU - Lee, Yong Keun

N1 - Funding Information: This work was supported by Grant No. R01-2001-000-00157 from the Basic Research Program of the Korea Science & Engineering Foundation.

PY - 2005/5/1

Y1 - 2005/5/1

N2 - We investigated the cytotoxicity of the prepared various ferrites (Fe-, Li-, Ni/Zn/Cu-, Ba-, Sr-, Co-, Co/Ni-ferrites) using MTT assay as well as agar diffusion method. Their cytotoxicity was compared with that of alginate-encapsulated ferrites. In the MTT assay, Fe3O4 and SrFe12O19 ferrite showed the highest cell viability of 90%. Alginate-encapsulated Ba-ferrite was ranked mildly cytotoxic, whereas their ferrite particles were ranked cytotoxic.

AB - We investigated the cytotoxicity of the prepared various ferrites (Fe-, Li-, Ni/Zn/Cu-, Ba-, Sr-, Co-, Co/Ni-ferrites) using MTT assay as well as agar diffusion method. Their cytotoxicity was compared with that of alginate-encapsulated ferrites. In the MTT assay, Fe3O4 and SrFe12O19 ferrite showed the highest cell viability of 90%. Alginate-encapsulated Ba-ferrite was ranked mildly cytotoxic, whereas their ferrite particles were ranked cytotoxic.

KW - Agar overlay assay

KW - Biocompatibility

KW - Co/Ni ferrite

KW - Cobalt ferrite

KW - Cytotoxicity

KW - Ferrite

KW - Hyperthermia

KW - MTT assay

KW - Magnetite

KW - SrFeO ferrite

KW - Toxicity

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DO - 10.1016/j.jmmm.2005.02.078

M3 - Article

AN - SCOPUS:18144397429

SN - 0304-8853

VL - 293

SP - 287

EP - 292

JO - Journal of Magnetism and Magnetic Materials

JF - Journal of Magnetism and Magnetic Materials

IS - 1

ER -

Cytotoxicity of ferrite particles by MTT and agar diffusion methods for hyperthermic application

Abstract

Keywords

ASJC Scopus subject areas

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