D1 and D2 dopamine-receptor modulation of striatal glutamatergic signaling in striatal medium spiny neurons

D. James Surmeier*, Jun Ding, Michelle Day, Zhongfeng Wang, Weixing Shen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

706 Scopus citations

Abstract

Dopamine shapes a wide variety of psychomotor functions. This is mainly accomplished by modulating cortical and thalamic glutamatergic signals impinging upon principal medium spiny neurons (MSNs) of the striatum. Several lines of evidence suggest that dopamine D1 receptor signaling enhances dendritic excitability and glutamatergic signaling in striatonigral MSNs, whereas D2 receptor signaling exerts the opposite effect in striatopallidal MSNs. The functional antagonism between these two major striatal dopamine receptors extends to the regulation of synaptic plasticity. Recent studies, using transgenic mice in which cells express D1 and D2 receptors, have uncovered unappreciated differences between MSNs that shape glutamatergic signaling and the influence of DA on synaptic plasticity. These studies have also shown that long-term alterations in dopamine signaling produce profound and cell-type-specific reshaping of corticostriatal connectivity and function.

Original languageEnglish (US)
Pages (from-to)228-235
Number of pages8
JournalTrends in Neurosciences
Volume30
Issue number5
DOIs
StatePublished - May 1 2007

ASJC Scopus subject areas

  • Neuroscience(all)

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