DA virus mutant H101 has altered CNS pathogenesis and causes immunosuppression

Matthew F. Cusick, Jane E. Libbey, Daniel J. Doty, Robert S. Fujinami*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Viruses use various mechanisms to evade clearance by the host. Investigating how a few changes in the genome of a non-lethal virus can lead to altered disease, from survivable to immunosuppression/death, would provide valuable information into viral pathogenesis. The Daniels strain of Theiler's murine encephalomyelitis virus causes an asymptomatic infection or acute encephalitis followed by viral clearance. A mutant, H101, carries several alterations in the viral genome. H101 infection causes profound immunosuppression and death. Thus, a virus that is normally cleared by its natural host can become lethal due to just a few changes in the viral genome.

Original languageEnglish (US)
Pages (from-to)118-126
Number of pages9
JournalJournal of Neuroimmunology
Volume277
Issue number1-2
DOIs
StatePublished - Dec 15 2014

Keywords

  • Immunosuppression
  • Picornavirus
  • T cell
  • Viral pathogenesis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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