Daily energy expenditure through the human life course

IAEA DLW Database Consortium

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Original languageEnglish (US)
Article numbereabe5017
JournalScience
Volume373
Issue number6556
DOIs
StatePublished - Aug 13 2021

ASJC Scopus subject areas

  • General

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