TY - JOUR
T1 - Daily Walking and the Risk of Knee Replacement Over 5 Years Among Adults With Advanced Knee Osteoarthritis in the United States
AU - Master, Hiral
AU - Thoma, Louise M.
AU - Neogi, Tuhina
AU - Dunlop, Dorothy D.
AU - LaValley, Michael
AU - Christiansen, Meredith B.
AU - Voinier, Dana
AU - White, Daniel K.
N1 - Funding Information:
Supported in part by the University Doctoral Fellowship Award from Unidel Foundation (award nos. R21-AR071079-01A1, K12HD055931-0y1, K23AR070913, T32-HD007490, F32AR073090, K24-AR070892, U54 GM104941). We have used publicly available data from the Osteoarthritis Initiative (OAI). The OAI is a public-private partnership composed of 5 contracts (nos. N01-AR-2258; N01-AR-2-2259; N01-AR-2-2260; N01-AR-2-2261; N01-AR-2-2262) funded by the National Institutes of Health (NIH), a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the NIH. This article was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
Funding Information:
Supported in part by the University Doctoral Fellowship Award from Unidel Foundation (award nos. R21-AR071079-01A1 , K12HD055931-01 , K23AR070913 , T32-HD007490 , F32AR073090 , K24-AR070892 , U54 GM104941). We have used publicly available data from the Osteoarthritis Initiative (OAI). The OAI is a public-private partnership composed of 5 contracts (nos. N01-AR-2258 ; N01-AR-2-2259 ; N01-AR-2-2260 ; N01-AR-2-2261 ; N01-AR-2-2262 ) funded by the National Institutes of Health (NIH), a branch of the Department of Health and Human Services, and conducted by the OAI Study Investigators. Private funding partners include Merck Research Laboratories, Novartis Pharmaceuticals Corporation, GlaxoSmithKline, and Pfizer, Inc. Private sector funding for the OAI is managed by the Foundation for the NIH. This article was prepared using an OAI public use data set and does not necessarily reflect the opinions or views of the OAI investigators, the NIH, or the private funding partners.
Publisher Copyright:
© 2021 The American Congress of Rehabilitation Medicine
PY - 2021/10
Y1 - 2021/10
N2 - Objective: To examine the association of the volume and intensity of daily walking at baseline with the risk of knee replacement (KR) over 5 years in adults with advanced structural knee osteoarthritis. Design: Prospective, longitudinal, and multicenter observational study. Setting: Osteoarthritis Initiative study with follow-up from 2008-2015. Participants: Community-dwelling adults with or at risk of knee osteoarthritis were recruited from 4 sites in the United States (N=516; mean age, 67.7±8.6y; body mass index, 29.3±4.7 kg/m2; 52% female). We included participants with advanced structural disease, without KR and had valid daily walking data (quantified using Actigraph GT1M), at baseline. Interventions: Not applicable. Main outcomes: KR. Walking volume was measured as steps/day and intensity as minutes/day spent not walking (0 steps/min) and walking at very light (1-49 steps/min), light (50-100 steps/min), or moderate (>100 steps/min) intensities. To examine the relationship of walking volume and intensity with the risk of KR, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for covariates. Results: Of 516 adults with advanced structural disease, 88 received a KR over 5 years (17%). Walking an additional 1000 steps/d was not associated with the risk of KR (adjusted HR=0.95; 95% CI, 0.84-1.04). Statistically, replacing 10 min/d of very light and light walking with 10 min/d of moderate walking reduced the risk of KR incidence by 35% and 37%, respectively (adjusted HR=0.65, 95% CI, 0.45-0.94, for very light and adjusted HR=0.63; 95% CI, 0.40-1.00, for light). Conclusions: Daily walking volume and intensity did not increase KR risk over 5 years and may be protective in some cases in adults with advanced structural knee osteoarthritis.
AB - Objective: To examine the association of the volume and intensity of daily walking at baseline with the risk of knee replacement (KR) over 5 years in adults with advanced structural knee osteoarthritis. Design: Prospective, longitudinal, and multicenter observational study. Setting: Osteoarthritis Initiative study with follow-up from 2008-2015. Participants: Community-dwelling adults with or at risk of knee osteoarthritis were recruited from 4 sites in the United States (N=516; mean age, 67.7±8.6y; body mass index, 29.3±4.7 kg/m2; 52% female). We included participants with advanced structural disease, without KR and had valid daily walking data (quantified using Actigraph GT1M), at baseline. Interventions: Not applicable. Main outcomes: KR. Walking volume was measured as steps/day and intensity as minutes/day spent not walking (0 steps/min) and walking at very light (1-49 steps/min), light (50-100 steps/min), or moderate (>100 steps/min) intensities. To examine the relationship of walking volume and intensity with the risk of KR, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for covariates. Results: Of 516 adults with advanced structural disease, 88 received a KR over 5 years (17%). Walking an additional 1000 steps/d was not associated with the risk of KR (adjusted HR=0.95; 95% CI, 0.84-1.04). Statistically, replacing 10 min/d of very light and light walking with 10 min/d of moderate walking reduced the risk of KR incidence by 35% and 37%, respectively (adjusted HR=0.65, 95% CI, 0.45-0.94, for very light and adjusted HR=0.63; 95% CI, 0.40-1.00, for light). Conclusions: Daily walking volume and intensity did not increase KR risk over 5 years and may be protective in some cases in adults with advanced structural knee osteoarthritis.
KW - Arthroplasty
KW - Exercise
KW - Pain
KW - Rehabilitation
KW - Replacement, knee
KW - Walking
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U2 - 10.1016/j.apmr.2021.05.014
DO - 10.1016/j.apmr.2021.05.014
M3 - Article
C2 - 34175271
AN - SCOPUS:85113506256
SN - 0003-9993
VL - 102
SP - 1888
EP - 1894
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 10
ER -