Dancing partners at the synapse: Auxiliary subunits that shape kainate receptor function

Bryan A. Copits, Geoffrey T. Swanson*

*Corresponding author for this work

Research output: Contribution to journalReview article

56 Scopus citations

Abstract

Kainate receptors are a family of ionotropic glutamate receptors whose physiological roles differ from those of other subtypes of glutamate receptors in that they predominantly serve as modulators, rather than mediators, of synaptic transmission. Neuronal kainate receptors exhibit unusually slow kinetic properties that have been difficult to reconcile with the behaviour of recombinant kainate receptors. Recently, however, the neuropilin and tolloid-like 1 (NETO1) and NETO2 proteins were identified as auxiliary kainate receptor subunits that shape both the biophysical properties and synaptic localization of these receptors.

Original languageEnglish (US)
Pages (from-to)675-686
Number of pages12
JournalNature Reviews Neuroscience
Volume13
Issue number10
DOIs
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Neuroscience(all)

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